ID   HXUC2_HAEIF             Reviewed;         725 AA.
AC   P45357;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Heme/hemopexin utilization protein C;
DE   Flags: Precursor;
GN   Name=hxuC;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=DL42 / Serotype B;
RX   PubMed=7751272; DOI=10.1128/jb.177.10.2644-2653.1995;
RA   Cope L.D., Yogev R., Mueller-Eberhard U., Hansen E.J.;
RT   "A gene cluster involved in the utilization of both free heme and
RT   heme:hemopexin by Haemophilus influenzae type b.";
RL   J. Bacteriol. 177:2644-2653(1995).
CC   -!- FUNCTION: Required for utilization of free heme at low concentrations.
CC       {ECO:0000269|PubMed:7751272}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; U09840; AAA87059.1; -; Genomic_DNA.
DR   PIR; A57148; A57148.
DR   AlphaFoldDB; P45357; -.
DR   SMR; P45357; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR011276; TonB_haem/Hb_rcpt.
DR   InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01785; TonB-hemin; 1.
DR   TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal; TonB box; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..725
FT                   /note="Heme/hemopexin utilization protein C"
FT                   /id="PRO_0000034763"
FT   MOTIF           708..725
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   725 AA;  80839 MW;  FC7886E020CB5BCE CRC64;
     MRFSKLSLAI ATTLVTANAL AQSVELDSIN VIATRDPSRF AYTPEKQSKD SLLSKQATSV
     AAALEDIPNV DIRGGSRSIA QKPNIRGLSD NRVVQVIDGV RQNFDLAHRG SYFLPMSLIQ
     EIEVIKGPSS SLWGSGALGG VVAMRTPNAL DLLKNNDKFG VKIRQGYQTA NNLSERDVSV
     FAANDKFDVL ISGFYNNADN LRTGKGNKLN NTAYKQFGGL AKFGWQINDA NRVELSHRET
     RFKQTAPSNN EVENELTNEQ ITDQIREFHK PNNGSPPKAK PSQEEFYSGV KTRFGSVSYL
     TDQQIPDQST VFNYYLTPDN PYLNTHIALY NNKTIEKEQR KVSGVKDQTK LTTRGINLRN
     SSELSHISFV YGVDYMRDKI RTERGTNNKD AQFRADPYNA NSNTTGVYLI AHIPLFGEKL
     LLSPSVRYDH YDTSSKTVKY KDNHLSPATK LTWIVTNWLD FTAKYNEAFR APSMQERFVS
     GSHFGTSILG RNEINKFVAN PNLRPETAKN KEITANLHFD SLFKQGDKFK IEATYFRNDV
     KDFINLKIFN DAKTNTNASA SAGAGAGANP NGALLPTKSQ YQNITNARLS GIELQAQYQT
     ERLTLFTNYG STKGKDKDSG EALSNIAASK IGVGVNYALV KDKFTVGATV THYAAQRRVP
     KDHSVTYPSY ILTDLRATYA PLKGEWKNLR LDFALENLFD RKYQPAFSLM EGTGRNAKIS
     AVYSF