ID   HXUC_HAEI8              Reviewed;         709 AA.
AC   Q4QNS6;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Heme/hemopexin utilization protein C;
DE   Flags: Precursor;
GN   Name=hxuC; OrderedLocusNames=NTHI0369;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=86-028NP;
RX   PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT   influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: Required for utilization of free heme at low concentrations.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; CP000057; AAX87321.1; -; Genomic_DNA.
DR   RefSeq; WP_011271952.1; NC_007146.2.
DR   AlphaFoldDB; Q4QNS6; -.
DR   SMR; Q4QNS6; -.
DR   EnsemblBacteria; AAX87321; AAX87321; NTHI0369.
DR   KEGG; hit:NTHI0369; -.
DR   HOGENOM; CLU_008287_19_3_6; -.
DR   OMA; AWEVGFN; -.
DR   OrthoDB; 439303at2; -.
DR   Proteomes; UP000002525; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR011276; TonB_haem/Hb_rcpt.
DR   InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01785; TonB-hemin; 1.
DR   TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal; TonB box; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..709
FT                   /note="Heme/hemopexin utilization protein C"
FT                   /id="PRO_0000230231"
FT   MOTIF           692..709
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   709 AA;  79293 MW;  21298CDAC73A2F9B CRC64;
     MRFSKLSLAI TTTLVTANAL AQSVELDSIN VIATRDPSRF TYTPQKQSKD SLLSKQATSV
     AAALEDIPNV DVRGGSRSIA QKPNIRGLSD NRVVQVIDGV RQNFDLAHRG SYFLPMSLIQ
     EIEVIKGPSS SLWGSGALGG VVAMRTPNAL DLLKNNDKFG VKIRQGYQTA NNLSEKDVSV
     FAANDKFDVL ISGFYNNADN LRIGKGNKLN NTAYKQFGGL AKFGWQINDA NRVELSHRET
     RFKQTAPGNN EAKNELTNEQ IIEKINEYHN PLNNFPPKAK PSLEEFYSGV RARLGGVSYL
     SDQQIPDQST VFNYYLTPDN PYLNTHIALY NNKTIEKEQR KVSGVKDQTK LTTRGINLRN
     SSELSHISFV YGVDYMRDKI STERGTNDKD AKFRAEPYNA NSNTTGVYLI AHIPLFGEKL
     LLSPSVRYDH YDTSSKTVKY KDNHLSPATK LTWKVTNWLD FTAKYNEAFR APSMQERFVS
     GAHFGTSTRV GDIINSFVAN PNLRPETAKN KEITANLHFD SLFKQGDKFK IEATYFRNDV
     KDLINLKRLD DPNANGALSR TNSQYQNIAN ARLSGIELQA QYQTERLTLF TNYGSTKGRD
     KDSGEALSNI AASKIGVGAD YALVKDKFTV GATITHYAAQ HRVPKDHAVT YPSYILTDLR
     ATYAPLKGEW KNLRLDFALE NLFDRKYQPA FSLMEGTGRN AKISAVYSF