HYAL_CONAQ
ID HYAL_CONAQ Reviewed; 347 AA.
AC I0CME8;
DT 31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2012, sequence version 1.
DT 25-MAY-2022, entry version 23.
DE RecName: Full=Hyaluronidase conohyal-ad1;
DE Short=Hya;
DE EC=3.2.1.35;
DE AltName: Full=Hyaluronoglucosaminidase;
DE Flags: Precursor; Fragment;
OS Conus adamsonii (Cone snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Textilia.
OX NCBI_TaxID=1173533;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=22412800; DOI=10.3390/md10020258;
RA Violette A., Leonardi A., Piquemal D., Terrat Y., Biass D., Dutertre S.,
RA Noguier F., Ducancel F., Stocklin R., Krizaj I., Favreau P.;
RT "Recruitment of glycosyl hydrolase proteins in a cone snail venomous
RT arsenal: further insights into biomolecular features of Conus venoms.";
RL Mar. Drugs 10:258-280(2012).
CC -!- FUNCTION: Hyaluronidase catalyzes the hydrolysis of hyaluronic acid
CC (HA), an anionic, nonsulfated glycosaminoglycan distributed widely
CC throughout connective, epithelial, and neural tissues. In venom, they
CC are known to enhance diffusion of the venom by degrading the
CC extracellular matrix (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-
CC glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- PTM: Contains 4 disulfide bonds. {ECO:0000250}.
CC -!- PTM: Is N-linked glycosylated at three positions. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family. {ECO:0000305}.
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DR EMBL; JN697597; AFH78529.1; -; mRNA.
DR AlphaFoldDB; I0CME8; -.
DR SMR; I0CME8; -.
DR CAZy; GH56; Glycoside Hydrolase Family 56.
DR ConoServer; 5536; conohyal-ad1 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.70; -; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR018155; Hyaluronidase.
DR PANTHER; PTHR11769; PTHR11769; 1.
DR Pfam; PF01630; Glyco_hydro_56; 1.
DR PIRSF; PIRSF038193; Hyaluronidase; 1.
DR PRINTS; PR00846; GLHYDRLASE56.
DR SUPFAM; SSF51445; SSF51445; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Glycosidase; Hydrolase; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..33
FT /evidence="ECO:0000250"
FT /id="PRO_0000419900"
FT CHAIN 34..>347
FT /note="Hyaluronidase conohyal-ad1"
FT /id="PRO_0000419901"
FT REGION 27..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 150
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT DISULFID 67..343
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT NON_TER 347
SQ SEQUENCE 347 AA; 39582 MW; A114DF88E0043228 CRC64;
MRAVVVVTGL VVVVVTTTLS LQDHDVKSAS SPLSSSVDQG SSGDDCDEGL PPPDQPFRVV
WNHPDNCEKI NLHLPLDEYG IIFNKRRVFL GEEIQTLYDT GPWPYINKTG CFINGGLPQL
FNQPDNSETC KILGKNRIED FTGLGVLDFE TWRAIYSTNF GTMENYQIES VNLVRKRHPD
YSEKELKMVA EQEWQEAARK IMTDKLAAGQ SLMPRGYWGY YLYPRTWDSK PDTKFRNNKI
DWLWRQSTGL YPSIYIYYDV VSKTDSVITK FVSDTVGEAV RVQNDFSPPN TPIYPYVMFQ
TMDNVFHKED HMKISLGLSA KMGAAGVILW GSSQNYKDFT TQCSRLQ