ID   HYAL_LYTVA              Reviewed;         530 AA.
AC   O96530;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Hyalin;
DE   Flags: Fragment;
OS   Lytechinus variegatus (Green sea urchin) (Echinus variegatus).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Temnopleuroida; Toxopneustidae; Lytechinus.
OX   NCBI_TaxID=7654;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9473317; DOI=10.1006/dbio.1997.8793;
RA   Wessel G.M., Berg L., Adelson D.L., Cannon G., McClay D.R.;
RT   "A molecular analysis of hyalin -- a substrate for cell adhesion in the
RT   hyaline layer of the sea urchin embryo.";
RL   Dev. Biol. 193:115-126(1998).
CC   -!- FUNCTION: Major constituent of the hyaline layer. The hyaline layer of
CC       echinoderm embryos is an extraembryonic matrix that functions as a
CC       substrate for cell adhesion through early development.
CC   -!- SUBUNIT: Homooligomer in presence of calcium.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix.
CC   -!- PTM: Glycosylated.
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DR   EMBL; AF076250; AAC72757.1; -; mRNA.
DR   AlphaFoldDB; O96530; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR003410; HYR_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF02494; HYR; 7.
DR   PROSITE; PS50825; HYR; 7.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Extracellular matrix; Glycoprotein; Repeat; Secreted.
FT   CHAIN           <1..>530
FT                   /note="Hyalin"
FT                   /id="PRO_0000084098"
FT   DOMAIN          <1..66
FT                   /note="HYR 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          67..150
FT                   /note="HYR 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          151..234
FT                   /note="HYR 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          235..319
FT                   /note="HYR 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          320..403
FT                   /note="HYR 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          404..486
FT                   /note="HYR 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          487..>530
FT                   /note="HYR 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   NON_TER         1
FT   NON_TER         530
SQ   SEQUENCE   530 AA;  55072 MW;  F37546CA43147CA3 CRC64;
     NVEIGTPSTT VTWTVPTAID ASAVTTVSSH NPGQSFITGT TTTVVYTATD EFGNIGQCAF
     TITVTATDSI DPVVTVSSGF ITQQVEIGLG GVNVFYTEPT ATDNSGTAVL FSRSAQPGDF
     FPVGQTVVTY IFQDPSGNFG TGTFTVNVVE VDTTPPVVTV PNGIITRQVE IGTSGIIVFF
     SEPTATDNSG TAILDSRTHQ PGDVFPVGQT IVTYTFRDPA GNPATGTFTI NVVEVDTTPP
     VITVPTPSII TRQVEVGTPG VSVFYQEPTA TDNSGTAILV SRTNQPGDVF PVGQTVVTYT
     FQDPSGNPAS ATVTINVVEV DTTPPVISVP STFITRTVEL GTPGVNVFYP EPTASDNSGT
     AILVTRTNQP GDFFSVGQTV VTYTFQDPTG NPATATVTIN IVEEDTTPPT VNCINDVIRT
     VELGTTSAQV FYSEPTASDV GQATLISRTA QPGDSFPVGA TVVTYIFGDN AGNIADPCVF
     TITVNTVDTT PPTVNCVSDV VRVVELGTTS LAVVYTEPTA TDISGTASLV