ID   HYAL_STRPU              Reviewed;        1200 AA.
AC   O76536;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Hyalin;
DE   Flags: Fragment;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9473317; DOI=10.1006/dbio.1997.8793;
RA   Wessel G.M., Berg L., Adelson D.L., Cannon G., McClay D.R.;
RT   "A molecular analysis of hyalin -- a substrate for cell adhesion in the
RT   hyaline layer of the sea urchin embryo.";
RL   Dev. Biol. 193:115-126(1998).
CC   -!- FUNCTION: Major constituent of the hyaline layer. The hyaline layer of
CC       echinoderm embryos is an extraembryonic matrix that functions as a
CC       substrate for cell adhesion through early development.
CC   -!- SUBUNIT: Homooligomer in presence of calcium.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix.
CC   -!- PTM: Glycosylated.
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DR   EMBL; AF076472; AAC31909.1; -; mRNA.
DR   PIR; T17404; T17404.
DR   AlphaFoldDB; O76536; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   InterPro; IPR003410; HYR_dom.
DR   Pfam; PF02494; HYR; 15.
DR   PROSITE; PS50825; HYR; 15.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Extracellular matrix; Glycoprotein; Reference proteome;
KW   Repeat; Secreted.
FT   CHAIN           <1..>1200
FT                   /note="Hyalin"
FT                   /id="PRO_0000084099"
FT   DOMAIN          <1..39
FT                   /note="HYR 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          40..123
FT                   /note="HYR 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          124..207
FT                   /note="HYR 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          208..292
FT                   /note="HYR 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          293..376
FT                   /note="HYR 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          377..460
FT                   /note="HYR 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          461..544
FT                   /note="HYR 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          546..629
FT                   /note="HYR 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          630..713
FT                   /note="HYR 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          714..797
FT                   /note="HYR 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          798..881
FT                   /note="HYR 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          882..966
FT                   /note="HYR 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          967..1050
FT                   /note="HYR 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          1051..1133
FT                   /note="HYR 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   DOMAIN          1134..>1200
FT                   /note="HYR 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00113"
FT   NON_TER         1
FT   NON_TER         1200
SQ   SEQUENCE   1200 AA;  124743 MW;  57A52B7CDE68A629 CRC64;
     SSHNPGQSFT TGTTTTVVYT ATDAFANVGQ CAFTITVTAT DTTPPVVTVS SSTITRQVEV
     GTPGVNVFFT EPTATDNSGQ AILISRTNQP GDFFSVGQTI VTYTFQDPSG NPASGTVTIN
     VIEVDTTPPV VTVPSTTITR QVEVGSSGVN VFYTEPTATD NSGQAILTSR TNQPGDFFPV
     GQTTVTYTFQ DPSGNPASGT VTINVIEVDT TPPVVTVPST TITRQVEVGS SGVNVFYTEP
     TATDNSGQAI LTSRTNQPGD FFPVGQTTVT YTFSQDPSGN PASATVTINV IEVDTTPPVV
     TVPSTTITRQ VEIGTPGVNV FYTEPTATDN SGIANLVSRT NQPGDFFPVG QTDVTYTFQD
     PSGNPSSGTV TINVVEVDTT SPVITVPSNT ITREVELGTP GVNVFYTEPT ATDNSGIANL
     VSRTNQPGDF FNVGQTVVTY TFQDPSGNPA SGTVTINVVE VDTTPPQVFV TTGEVVRTAP
     FGSSGVNVFF TEPVAIDNSG TADLVSQTAQ PGDFFPIGST VVTYRYRDAS GNEATGTFTV
     TVEEMVDTTP PTVTVSGGNI VRTVELGQSR LSVIYTEPTA TDNSGEANLV SRTAQPGDLF
     PVGTTTVEYV YQDPAGNEGR GQFTVTVIAV DTTPPSVNCP NNVFQEVELG TSSAPVFFTE
     PTAFDISGQA NLVTRTAAPG DSFPVGTTSV SYIFSDNSGN EAEPCTFTVT ISAVDTTPPT
     VNCINNVAQT VQLGTGSTQV FFTEPTAFDI SGQTSLVTRT SAPGDSFPVG TTSVTYIFTD
     ASGNNAQPCT FNVVINAVDT TPPTVNCANN IAQTIELGST SAVVNYAEPS ATDISGTAFL
     VSRSSSPGDS FPIGSTTVTY IFSDQSGNEA PPCVFTVTIG TVDTMMPMFT SCPNNIVQSV
     ELGVPGTVIS WTTPTANDAA GIASIVSNLQ PGSFFTVGES ATVTYVATDN SGLTDNSCSF
     TVTVFAVDTT PPSVVCTNNV FQTVELGTNP VQVFYTEPTA SDISGQANLV SRTNVPGDSF
     PVGTSTVTYV FADNSGNTAD ACSFTITVTA QDTTPPTVNC ITNIVRTVEL GTSSVQVFYN
     EPTASDLGQA SLVSRTAQPG DNFPVGVNPV TYVFGDNSGN QADPCTFTIT VNTQDTTPPT
     VTCISDITRV VELGTTSVGI SYTEPTATDI SGTATLDSRS HTPGQNFPVG STVVSYFFSD