HYBF_SHIFL
ID HYBF_SHIFL Reviewed; 113 AA.
AC P0A704; P37184; Q46846;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Hydrogenase maturation factor HybF {ECO:0000255|HAMAP-Rule:MF_02099};
GN Name=hybF {ECO:0000255|HAMAP-Rule:MF_02099};
GN OrderedLocusNames=SF3038, S3239;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Involved in the maturation of [NiFe] hydrogenases. Required
CC for nickel insertion into the metal center of the hydrogenase.
CC {ECO:0000255|HAMAP-Rule:MF_02099}.
CC -!- SIMILARITY: Belongs to the HypA/HybF family. HybF subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_02099}.
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DR EMBL; AE005674; AAN44516.2; -; Genomic_DNA.
DR EMBL; AE014073; AAP18327.1; -; Genomic_DNA.
DR RefSeq; NP_708809.2; NC_004337.2.
DR RefSeq; WP_000544953.1; NZ_WPGW01000034.1.
DR AlphaFoldDB; P0A704; -.
DR SMR; P0A704; -.
DR STRING; 198214.SF3038; -.
DR EnsemblBacteria; AAN44516; AAN44516; SF3038.
DR EnsemblBacteria; AAP18327; AAP18327; S3239.
DR GeneID; 1026631; -.
DR GeneID; 58459877; -.
DR KEGG; sfl:SF3038; -.
DR KEGG; sfx:S3239; -.
DR PATRIC; fig|198214.7.peg.3612; -.
DR HOGENOM; CLU_126929_0_0_6; -.
DR OMA; ILLCPCG; -.
DR OrthoDB; 1995603at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051604; P:protein maturation; IEA:InterPro.
DR HAMAP; MF_02099; HybF_subfam; 1.
DR HAMAP; MF_00213; HypA_HybF; 1.
DR InterPro; IPR039002; HybF.
DR InterPro; IPR020538; Hydgase_Ni_incorp_HypA/HybF_CS.
DR InterPro; IPR000688; HypA/HybF.
DR PANTHER; PTHR34535; PTHR34535; 1.
DR Pfam; PF01155; HypA; 1.
DR PIRSF; PIRSF004761; Hydrgn_mat_HypA; 1.
DR TIGRFAMs; TIGR00100; hypA; 1.
DR PROSITE; PS01249; HYPA; 1.
PE 3: Inferred from homology;
KW Metal-binding; Nickel; Reference proteome; Zinc.
FT CHAIN 1..113
FT /note="Hydrogenase maturation factor HybF"
FT /id="PRO_0000129071"
FT BINDING 2
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02099"
FT BINDING 3
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02099"
FT BINDING 73
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02099"
FT BINDING 76
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02099"
FT BINDING 89
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02099"
FT BINDING 92
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02099"
SQ SEQUENCE 113 AA; 12697 MW; 70919C4A40CEABE6 CRC64;
MHELSLCQSA VEIIQRQAEQ HDVKRVTAVW LEIGALSCVE ESAVRFSFEI VCHGTVAQGC
DLHIVYKPAQ AWCWDCSQVV EIHQHDAQCP LCHGERLRVD TGDSLIVKSI EVE
