ID   HYBG_ECO57              Reviewed;          82 AA.
AC   P0AAM9; P37185;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Hydrogenase maturation factor HybG {ECO:0000250|UniProtKB:P0AAM7};
GN   Name=hybG; OrderedLocusNames=Z4344, ECs3875;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Involved in the maturation of [NiFe] hydrogenases. Involved
CC       in the biosynthesis of the Fe(CN)(2)CO cofactor. HybG delivers iron-
CC       bound CO(2) to HypD where reduction to CO probably occurs. In complex
CC       with HypD, accepts the cyanide ligand generated by HypF and HypE, and
CC       also coordinates the carbon monoxide ligand.
CC       {ECO:0000250|UniProtKB:P0AAM7}.
CC   -!- PATHWAY: Protein modification; [NiFe] hydrogenase maturation.
CC       {ECO:0000250|UniProtKB:P0AAM7}.
CC   -!- SIMILARITY: Belongs to the HupF/HypC family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG58127.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37298.1; -; Genomic_DNA.
DR   PIR; C85958; C85958.
DR   PIR; C91113; C91113.
DR   RefSeq; NP_311902.1; NC_002695.1.
DR   RefSeq; WP_000334896.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AAM9; -.
DR   SMR; P0AAM9; -.
DR   STRING; 155864.EDL933_4212; -.
DR   EnsemblBacteria; AAG58127; AAG58127; Z4344.
DR   EnsemblBacteria; BAB37298; BAB37298; ECs_3875.
DR   GeneID; 67415062; -.
DR   GeneID; 916301; -.
DR   KEGG; ece:Z4344; -.
DR   KEGG; ecs:ECs_3875; -.
DR   PATRIC; fig|386585.9.peg.4042; -.
DR   eggNOG; COG0298; Bacteria.
DR   HOGENOM; CLU_159381_1_1_6; -.
DR   OMA; HYPARVD; -.
DR   UniPathway; UPA00335; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   InterPro; IPR019812; Hydgase_assmbl_chp_CS.
DR   InterPro; IPR001109; Hydrogenase_HupF/HypC.
DR   PANTHER; PTHR35177; PTHR35177; 1.
DR   Pfam; PF01455; HupF_HypC; 1.
DR   PRINTS; PR00445; HUPFHYPC.
DR   TIGRFAMs; TIGR00074; hypC_hupF; 1.
DR   PROSITE; PS01097; HUPF_HYPC; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..82
FT                   /note="Hydrogenase maturation factor HybG"
FT                   /id="PRO_0000201404"
FT   SITE            2
FT                   /note="Important for interaction with HypD and the
FT                   precursor form of hydrogenase"
FT                   /evidence="ECO:0000250|UniProtKB:P0AAM3"
SQ   SEQUENCE   82 AA;  8808 MW;  8E9736BFC4EFD626 CRC64;
     MCIGVPGQVL AVGEDIHQLA QVEVCGIKRD VNIALICEGN PADLLGQWVL VHVGFAMSII
     DEDEAKATLD ALRQMDYDIT SA