ID   HYCA_ECO57              Reviewed;         153 AA.
AC   P0AEV5; P16427;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Formate hydrogenlyase regulatory protein HycA;
GN   Name=hycA; OrderedLocusNames=Z4033, ECs3581;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Regulatory protein for the formate hydrogenlyase system.
CC       Could act by directly interacting with FhlA or by preventing the
CC       binding of FhlA to the upstream activatory sequence (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; AE005174; AAG57832.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37004.1; -; Genomic_DNA.
DR   PIR; D85921; D85921.
DR   PIR; E91076; E91076.
DR   RefSeq; NP_311608.1; NC_002695.1.
DR   RefSeq; WP_000158056.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AEV5; -.
DR   STRING; 155864.EDL933_3894; -.
DR   EnsemblBacteria; AAG57832; AAG57832; Z4033.
DR   EnsemblBacteria; BAB37004; BAB37004; ECs_3581.
DR   GeneID; 66673406; -.
DR   GeneID; 914697; -.
DR   KEGG; ece:Z4033; -.
DR   KEGG; ecs:ECs_3581; -.
DR   PATRIC; fig|386585.9.peg.3742; -.
DR   eggNOG; ENOG50305VH; Bacteria.
DR   HOGENOM; CLU_115336_0_0_6; -.
DR   OMA; HAMSCAA; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   InterPro; IPR021285; Tscrpt_reg_HycA.
DR   Pfam; PF11046; HycA_repressor; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..153
FT                   /note="Formate hydrogenlyase regulatory protein HycA"
FT                   /id="PRO_0000084101"
SQ   SEQUENCE   153 AA;  17627 MW;  CB61EC856450A0AD CRC64;
     MTIWEISEKA DYIAQRHRRL QDQWHIYCNS LVQGITLSKA RLHHAMSCAP DKELCFVLFE
     HFRIYVTLAD GFNSHTIEYY VETKDGEDKQ RIAQAQLSID GMIDGKVNIR DREQVLEHYL
     EKIAGVYDSL YTAIENNVPV NLSQLVKGQS PAA