ID   HYCA_SHIFL              Reviewed;         153 AA.
AC   P0AEV6; P16427;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Formate hydrogenlyase regulatory protein HycA;
GN   Name=hycA; OrderedLocusNames=SF2742, S2934;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Regulatory protein for the formate hydrogenlyase system.
CC       Could act by directly interacting with FhlA or by preventing the
CC       binding of FhlA to the upstream activatory sequence (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; AE005674; AAN44233.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18060.1; -; Genomic_DNA.
DR   RefSeq; NP_708526.1; NC_004337.2.
DR   RefSeq; WP_000158056.1; NZ_WPGW01000014.1.
DR   AlphaFoldDB; P0AEV6; -.
DR   STRING; 198214.SF2742; -.
DR   EnsemblBacteria; AAN44233; AAN44233; SF2742.
DR   EnsemblBacteria; AAP18060; AAP18060; S2934.
DR   GeneID; 1025724; -.
DR   GeneID; 66673406; -.
DR   KEGG; sfl:SF2742; -.
DR   KEGG; sfx:S2934; -.
DR   PATRIC; fig|198214.7.peg.3265; -.
DR   HOGENOM; CLU_115336_0_0_6; -.
DR   OMA; HAMSCAA; -.
DR   OrthoDB; 1349303at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   InterPro; IPR021285; Tscrpt_reg_HycA.
DR   Pfam; PF11046; HycA_repressor; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..153
FT                   /note="Formate hydrogenlyase regulatory protein HycA"
FT                   /id="PRO_0000084102"
SQ   SEQUENCE   153 AA;  17627 MW;  CB61EC856450A0AD CRC64;
     MTIWEISEKA DYIAQRHRRL QDQWHIYCNS LVQGITLSKA RLHHAMSCAP DKELCFVLFE
     HFRIYVTLAD GFNSHTIEYY VETKDGEDKQ RIAQAQLSID GMIDGKVNIR DREQVLEHYL
     EKIAGVYDSL YTAIENNVPV NLSQLVKGQS PAA