HYCCI_CHICK
ID HYCCI_CHICK Reviewed; 515 AA.
AC Q5ZM13; F1NT76;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 17-FEB-2016, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Hyccin;
DE AltName: Full=Down-regulated by CTNNB1 protein A;
DE AltName: Full=Protein FAM126A;
GN Name=FAM126A; Synonyms=DRCTNNB1A; ORFNames=RCJMB04_3h8;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND IDENTIFICATION.
RC STRAIN=Red jungle fowl;
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
CC -!- FUNCTION: Component of a complex required to localize
CC phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The
CC complex acts as a regulator of phosphatidylinositol 4-phosphate
CC (PtdIns(4)P) synthesis. {ECO:0000250|UniProtKB:Q9BYI3}.
CC -!- SUBUNIT: Component of a phosphatidylinositol 4-kinase (PI4K) complex.
CC {ECO:0000250|UniProtKB:Q9BYI3}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q9BYI3}. Cell membrane
CC {ECO:0000250|UniProtKB:Q9BYI3}.
CC -!- SIMILARITY: Belongs to the FAM126 family. {ECO:0000305}.
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DR EMBL; AJ719571; CAG31230.1; -; mRNA.
DR EMBL; AADN03001856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001026154.2; NM_001030983.2.
DR RefSeq; XP_015136924.1; XM_015281438.1.
DR AlphaFoldDB; Q5ZM13; -.
DR SMR; Q5ZM13; -.
DR STRING; 9031.ENSGALP00000017753; -.
DR PaxDb; Q5ZM13; -.
DR Ensembl; ENSGALT00000017774; ENSGALP00000017753; ENSGALG00000010925.
DR Ensembl; ENSGALT00000081617; ENSGALP00000048560; ENSGALG00000010925.
DR Ensembl; ENSGALT00000083624; ENSGALP00000058693; ENSGALG00000010925.
DR Ensembl; ENSGALT00000092398; ENSGALP00000066862; ENSGALG00000010925.
DR GeneID; 420611; -.
DR KEGG; gga:420611; -.
DR CTD; 84668; -.
DR VEuPathDB; HostDB:geneid_420611; -.
DR eggNOG; KOG4688; Eukaryota.
DR GeneTree; ENSGT00390000011295; -.
DR InParanoid; Q5ZM13; -.
DR OMA; TAGESCK; -.
DR OrthoDB; 673408at2759; -.
DR TreeFam; TF317153; -.
DR PRO; PR:Q5ZM13; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000010925; Expressed in spermatid and 14 other tissues.
DR ExpressionAtlas; Q5ZM13; baseline and differential.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0042552; P:myelination; ISS:UniProtKB.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; ISS:UniProtKB.
DR GO; GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
DR InterPro; IPR018619; Hyccin.
DR PANTHER; PTHR31220; PTHR31220; 1.
DR Pfam; PF09790; Hyccin; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasm; Membrane; Reference proteome.
FT CHAIN 1..515
FT /note="Hyccin"
FT /id="PRO_0000080004"
FT REGION 358..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 228..229
FT /note="SR -> RI (in Ref. 1; CAG31230)"
FT CONFLICT 235
FT /note="E -> S (in Ref. 1; CAG31230)"
FT CONFLICT 254..261
FT /note="DLARKAMD -> MIWLVRLW (in Ref. 1; CAG31230)"
FT CONFLICT 289
FT /note="G -> S (in Ref. 1; CAG31230)"
FT CONFLICT 418
FT /note="V -> L (in Ref. 1; CAG31230)"
SQ SEQUENCE 515 AA; 56995 MW; C6FD1E1E1CC6894A CRC64;
MLAVDTGLVE EWLSEFKTLP EASISSYATN LKDKTALISS LYKVIQEPQS ELLEPVCHQL
FEFYRSGEEQ LLRFTLQFLP ELMWCYLAVS ASRDLQSSGC IEALLLGVYN LEIVDKEGHS
KVLSFTIPSL SKPSVYHEPS SIGSMALTEG ALSQHGLSRV VYSGPHPQRE MLTAQNRFEV
LTFLLLCYNA ALSYMPAISL QSLCQICSRI CVCGYPRQQV RKYKGVNSRI PVSSEFMVQM
LTGIYYAFYN GEWDLARKAM DDVLYRAQLE LYPEPLLVAN AIKASLPQGA MKSSKEGTKC
IQVEITPTSS RISRNAVTSM SIRGHRWKRH GNADLGIEEE LIEVSETDEG FYSRAASSTS
QSALSNSSNT SSKNLLGKSQ RRSGGSKAAG REKEGETCRE HLSRKQTQRA LSENLELVSL
KRLTLTTSQS LPKPGSHSLA RTTTTVFSKS FEQVSGVTVA NNRGGVSGTE ANRFSACSLQ
EEKLIYGTER TDLPVLSKQP NQQRPPSISI TLSTD
