ID   HYCCI_DANRE             Reviewed;         518 AA.
AC   Q6P121;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Hyccin;
DE   AltName: Full=Protein FAM126A;
GN   Name=fam126a; ORFNames=zgc:77228;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a complex required to localize
CC       phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The
CC       complex acts as a regulator of phosphatidylinositol 4-phosphate
CC       (PtdIns(4)P) synthesis. {ECO:0000250|UniProtKB:Q9BYI3}.
CC   -!- SUBUNIT: Component of a phosphatidylinositol 4-kinase (PI4K) complex.
CC       {ECO:0000250|UniProtKB:Q9BYI3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9BYI3}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q9BYI3}.
CC   -!- SIMILARITY: Belongs to the FAM126 family. {ECO:0000305}.
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DR   EMBL; BC065326; AAH65326.1; -; mRNA.
DR   RefSeq; NP_991193.1; NM_205630.1.
DR   RefSeq; XP_005173793.1; XM_005173736.3.
DR   RefSeq; XP_005173795.1; XM_005173738.3.
DR   AlphaFoldDB; Q6P121; -.
DR   SMR; Q6P121; -.
DR   STRING; 7955.ENSDARP00000036397; -.
DR   PaxDb; Q6P121; -.
DR   Ensembl; ENSDART00000033132; ENSDARP00000036397; ENSDARG00000026762.
DR   GeneID; 402926; -.
DR   KEGG; dre:402926; -.
DR   CTD; 84668; -.
DR   ZFIN; ZDB-GENE-040426-1806; fam126a.
DR   eggNOG; KOG4688; Eukaryota.
DR   GeneTree; ENSGT00390000011295; -.
DR   HOGENOM; CLU_027457_3_0_1; -.
DR   InParanoid; Q6P121; -.
DR   OMA; TAGESCK; -.
DR   OrthoDB; 673408at2759; -.
DR   PhylomeDB; Q6P121; -.
DR   TreeFam; TF317153; -.
DR   PRO; PR:Q6P121; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000026762; Expressed in retina and 21 other tissues.
DR   ExpressionAtlas; Q6P121; baseline.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0042552; P:myelination; ISS:UniProtKB.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
DR   InterPro; IPR018619; Hyccin.
DR   PANTHER; PTHR31220; PTHR31220; 1.
DR   Pfam; PF09790; Hyccin; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..518
FT                   /note="Hyccin"
FT                   /id="PRO_0000278093"
FT   REGION          385..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          466..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..407
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..485
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   518 AA;  56428 MW;  6D04541501CEB881 CRC64;
     MLAMDQGVVE EWLSEFKTLE ETAVYNYAVS LKEKGSLVPA LYKVIRENYS DLLEPVCHQL
     FEFYRSGEPR LQRFTLQFLP ELVWSYLSVT AARDPHCSGC IEALLLGIYN LEIVDKDGQS
     KVLSFTIPSL SKPSVYHEPS SIGSLALTEG ALANHGLSRV VYSGPHLQRE TFTAQNRFEV
     LTFLLLCYNA SLSYMSGSSL QSLCQLSSRV SICGYPRQQV RRYKGISSRL MVTSEFLVQL
     ITGIHFALCN GEVDLGSKAL DDVLYRAQLE LFPEALLVGN AIKSSLHGAS LKSNKEGTRS
     IQVEITPTAS RISRNAVTSL SIRGHRWKRH DAVDLGSPDE LTEIAEVDEG ICTQASGAQS
     SPPTIVISSS AGGAAAGAGK LAGKGLRRLT GRSSKEKDKE KDAATGMDQL TRKQAAVRAM
     SENLELLSLK RLTLTASQSV PKSGSLSLSR TASAVFSRSF EQVSNVFSGN QPSSRASSPT
     SNHVAEQDEG VAYLDHISPA HQHRQRSPTI SIHVTSDL