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HYCF_ECOLI
ID   HYCF_ECOLI              Reviewed;         180 AA.
AC   P16432; Q2MAA9;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 159.
DE   RecName: Full=Formate hydrogenlyase subunit 6;
DE            Short=FHL subunit 6;
DE   AltName: Full=Hydrogenase-3 component F;
GN   Name=hycF; Synonyms=hevF; OrderedLocusNames=b2720, JW2690;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
RX   PubMed=2187144; DOI=10.1111/j.1365-2958.1990.tb00590.x;
RA   Boehm R., Sauter M., Boeck A.;
RT   "Nucleotide sequence and expression of an operon in Escherichia coli coding
RT   for formate hydrogenlyase components.";
RL   Mol. Microbiol. 4:231-243(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Probable electron transfer protein for hydrogenase 3.
CC   -!- SUBUNIT: FHL comprises of a formate dehydrogenase, unidentified
CC       electron carriers and a hydrogenase (isoenzyme 3). In this non-energy
CC       conserving pathway, molecular hydrogen and carbodioxide are released
CC       from formate.
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DR   EMBL; X17506; CAA35551.1; -; Genomic_DNA.
DR   EMBL; U29579; AAA69230.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75762.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76797.1; -; Genomic_DNA.
DR   PIR; S08624; S08624.
DR   RefSeq; NP_417200.1; NC_000913.3.
DR   RefSeq; WP_000493781.1; NZ_LN832404.1.
DR   AlphaFoldDB; P16432; -.
DR   BioGRID; 4262940; 11.
DR   BioGRID; 851386; 1.
DR   ComplexPortal; CPX-317; Formate hydrogenlyase-H/Hydrogenase-3 complex.
DR   IntAct; P16432; 10.
DR   MINT; P16432; -.
DR   STRING; 511145.b2720; -.
DR   TCDB; 3.D.1.9.2; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR   PaxDb; P16432; -.
DR   PRIDE; P16432; -.
DR   EnsemblBacteria; AAC75762; AAC75762; b2720.
DR   EnsemblBacteria; BAE76797; BAE76797; BAE76797.
DR   GeneID; 947048; -.
DR   KEGG; ecj:JW2690; -.
DR   KEGG; eco:b2720; -.
DR   PATRIC; fig|1411691.4.peg.4021; -.
DR   EchoBASE; EB0474; -.
DR   eggNOG; COG1143; Bacteria.
DR   HOGENOM; CLU_067218_3_1_6; -.
DR   InParanoid; P16432; -.
DR   OMA; AEHHRES; -.
DR   PhylomeDB; P16432; -.
DR   BioCyc; EcoCyc:HYCF-MON; -.
DR   BioCyc; MetaCyc:HYCF-MON; -.
DR   PRO; PR:P16432; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0009326; C:formate dehydrogenase complex; IPI:ComplexPortal.
DR   GO; GO:0016020; C:membrane; IDA:ComplexPortal.
DR   GO; GO:0045272; C:plasma membrane respiratory chain complex I; IBA:GO_Central.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR   GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR   GO; GO:0019645; P:anaerobic electron transport chain; IDA:ComplexPortal.
DR   GO; GO:0009061; P:anaerobic respiration; IDA:ComplexPortal.
DR   GO; GO:0015944; P:formate oxidation; IDA:ComplexPortal.
DR   GO; GO:0006007; P:glucose catabolic process; IDA:ComplexPortal.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR010226; NADH_quinone_OxRdtase_chainI.
DR   PANTHER; PTHR10849; PTHR10849; 1.
DR   Pfam; PF12838; Fer4_7; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 2.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   4: Predicted;
KW   4Fe-4S; Electron transport; Iron; Iron-sulfur; Metal-binding;
KW   Reference proteome; Repeat; Transport.
FT   CHAIN           1..180
FT                   /note="Formate hydrogenlyase subunit 6"
FT                   /id="PRO_0000159266"
FT   DOMAIN          31..60
FT                   /note="4Fe-4S ferredoxin-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00711"
FT   DOMAIN          66..95
FT                   /note="4Fe-4S ferredoxin-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00711"
FT   BINDING         40
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         43
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         46
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         50
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         75
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         78
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         81
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         85
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   180 AA;  20309 MW;  284B8C507B47DFDC CRC64;
     MFTFIKKVIK TGTATSSYPL EPIAVDKNFR GKPEQNPQQC IGCAACVNAC PSNALTVETD
     LATGELAWEF NLGHCIFCGR CEEVCPTAAI KLSQEYELAV WKKEDFLQQS RFALCNCRVC
     NRPFAVQKEI DYAIALLKHN GDSRAENHRE SFETCPECKR QKCLVPSDRI ELTRHMKEAI
 
 
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