ID   HYDL_STRHA              Reviewed;         555 AA.
AC   Q05355;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Putative polyketide hydroxylase;
DE            EC=1.14.13.-;
GN   Name=schC;
OS   Streptomyces halstedii.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NRRL 2381;
RX   PubMed=8253693; DOI=10.1128/jb.175.24.8043-8048.1993;
RA   Blanco G., Pereda A., Brian P., Mendez C., Chater K.F., Salas J.A.;
RT   "A hydroxylase-like gene product contributes to synthesis of a polyketide
RT   spore pigment in Streptomyces halstedii.";
RL   J. Bacteriol. 175:8043-8048(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-75.
RC   STRAIN=NRRL 2381;
RX   PubMed=8344517; DOI=10.1016/0378-1119(93)90352-4;
RA   Blanco G., Brian P., Pereda A., Mendez C., Salas J.A., Chater K.F.;
RT   "Hybridization and DNA sequence analyses suggest an early evolutionary
RT   divergence of related biosynthetic gene sets encoding polyketide
RT   antibiotics and spore pigments in Streptomyces spp.";
RL   Gene 130:107-116(1993).
CC   -!- FUNCTION: Involved in developmentally regulated synthesis of a compound
CC       biosynthetically related to polyketide antibiotics which is essential
CC       for spore color in Streptomyces halstedii.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the PheA/TfdB FAD monooxygenase family.
CC       {ECO:0000305}.
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DR   EMBL; L05390; AAA02830.2; -; Genomic_DNA.
DR   PIR; B49918; B49918.
DR   AlphaFoldDB; Q05355; -.
DR   SMR; Q05355; -.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR002938; FAD-bd.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   Pfam; PF01494; FAD_binding_3; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN           1..555
FT                   /note="Putative polyketide hydroxylase"
FT                   /id="PRO_0000214042"
FT   REGION          366..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         16..45
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
FT   BINDING         303..313
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   555 AA;  59379 MW;  23CCF55BF6738D58 CRC64;
     MNARADRAGD TVHRVPVLVV GGSLVGLSTS VFLGRLGVRH MLVERHAGTS VHPRGRGNNV
     RTMEVYRAAG VEQGIRRAAA TLAGNHGILQ TPSLVGDEGE WLLRDIDPGG GLARFSPSSW
     CLCSQNDLEP VLLDHAVELG GEIRFSTELQ SFEQDPAGVT AVIKSRRSGE HTTVRADYLV
     AADGPRSPVR EQLGIGQSGP GDLFHNVSVT FRSRRLAEFV GDRHFIVCYL TNPEADGALL
     PVDNRENWVF HAPWYPRAAR PLEDFTDERC ADHIRRAVGV PDLDVEITGK APWHAAQRVA
     RQYRAGRVFL AGDSAHEMSP TGAFGSNTGI QDAHNLAWKL AAVLGGWAGD GLLDTYDAER
     RPVAEATTAR AAARSAEHSH PGFAPPPGTS GGPQGGILNV ALGYRYPGGA VLGADPATPV
     VPEALTLAGE PGSRAPHLWM SRRGERLSTL DLYERSPVLL SDADAGAPDA WHESAVRLAE
     ELSVPLTSYR VGRSAGADLT PEDDVNWTAR HGTPPGGAVL VRPDGFVAWR SQEPVPAEET
     EPTLRHVLTT VLSLG