ID   HYEP_STIAD              Reviewed;         440 AA.
AC   Q06816; Q08V44;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Putative epoxide hydrolase;
DE            EC=3.3.2.10;
DE   AltName: Full=Epoxide hydratase;
DE   Flags: Precursor;
GN   OrderedLocusNames=STAUR_4299; ORFNames=STIAU_6512;
OS   Stigmatella aurantiaca (strain DW4/3-1).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Archangiaceae; Stigmatella.
OX   NCBI_TaxID=378806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DW4/3-1;
RX   PubMed=8226695; DOI=10.1128/jb.175.22.7479-7482.1993;
RA   Heidelbach M., Skladny H., Schairer H.U.;
RT   "Heat shock and development induce synthesis of a low-molecular-weight
RT   stress-responsive protein in the myxobacterium Stigmatella aurantiaca.";
RL   J. Bacteriol. 175:7479-7482(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DW4/3-1;
RA   Nierman W.C.;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DW4/3-1;
RX   PubMed=21037205; DOI=10.1093/molbev/msq292;
RA   Huntley S., Hamann N., Wegener-Feldbruegge S., Treuner-Lange A., Kube M.,
RA   Reinhardt R., Klages S., Mueller R., Ronning C.M., Nierman W.C.,
RA   Sogaard-Andersen L.;
RT   "Comparative genomic analysis of fruiting body formation in Myxococcales.";
RL   Mol. Biol. Evol. 28:1083-1097(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an epoxide + H2O = an ethanediol; Xref=Rhea:RHEA:19037,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:32955, ChEBI:CHEBI:140594;
CC         EC=3.3.2.10;
CC   -!- PTM: Predicted to be exported by the Tat system. The position of the
CC       signal peptide cleavage has not been experimentally proven.
CC   -!- SIMILARITY: Belongs to the peptidase S33 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA16137.1; Type=Miscellaneous discrepancy; Note=Chimera. Seems to include DNA from another gene.; Evidence={ECO:0000305};
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DR   EMBL; M94510; AAA16137.1; ALT_SEQ; Unassigned_DNA.
DR   EMBL; AAMD01000121; EAU64350.1; -; Genomic_DNA.
DR   EMBL; CP002271; ADO72079.1; -; Genomic_DNA.
DR   PIR; S27670; S27670.
DR   RefSeq; WP_002616688.1; NZ_AAMD01000121.1.
DR   AlphaFoldDB; Q06816; -.
DR   SMR; Q06816; -.
DR   STRING; 378806.STAUR_4299; -.
DR   ESTHER; stiau-EPHA; Epoxide_hydrolase.
DR   MEROPS; S33.971; -.
DR   EnsemblBacteria; ADO72079; ADO72079; STAUR_4299.
DR   EnsemblBacteria; EAU64350; EAU64350; STIAU_6512.
DR   KEGG; sur:STAUR_4299; -.
DR   PATRIC; fig|378806.16.peg.3264; -.
DR   eggNOG; COG0596; Bacteria.
DR   HOGENOM; CLU_019414_0_1_7; -.
DR   OMA; GQAAWMY; -.
DR   OrthoDB; 1890883at2; -.
DR   Proteomes; UP000001351; Chromosome.
DR   Proteomes; UP000032702; Unassembled WGS sequence.
DR   GO; GO:0033961; F:cis-stilbene-oxide hydrolase activity; IEA:InterPro.
DR   GO; GO:0004301; F:epoxide hydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000639; Epox_hydrolase-like.
DR   InterPro; IPR010497; Epoxide_hydro_N.
DR   InterPro; IPR016292; Epoxide_hydrolase.
DR   InterPro; IPR006311; TAT_signal.
DR   Pfam; PF06441; EHN; 1.
DR   PIRSF; PIRSF001112; Epoxide_hydrolase; 1.
DR   PRINTS; PR00412; EPOXHYDRLASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS51318; TAT; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; Hydrolase; Reference proteome; Signal.
FT   SIGNAL          1..49
FT                   /note="Tat-type signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00648"
FT   CHAIN           50..440
FT                   /note="Putative epoxide hydrolase"
FT                   /id="PRO_0000084109"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   440 AA;  48153 MW;  EED7BD16F81A404A CRC64;
     MTKTLAEQPG EGAAPVSPSP SRRALLHGAA GLGALAAGAA VAGPGLAFAA PAGLPLPPAT
     PGITPFKIAV PQSALTDLKR RLGATRWPER ETVEDWSQGV PLAKLQGLVE YWRTRYDWRR
     AEATLNRFPN YRTQLDGLGI HFLHARSKHE NALPILLTHG WPGSVIEFLK LIPLLTDPTA
     HGGKAEDAFH VILPSLPGFG FSDKPTQKGW NMARIAKAWA ELMQRLGYTH WVAQGGDWGA
     GVTTALAHLQ PAGLAGIHLN FPLVFPEKLP TTDLSPEEQR ALAQAQAFNT HGSGYFLLQT
     TRPQTVGYAL ADSPSGQAAW IYEKFQGWTD NKGDPESALS QDEMLDNISL YWLTDTAASS
     ARIYWENAGS NFSGGKLDLP VGVSVFPREL FRAPKRWAEQ TYSKLIYWNE PDRGGHFAAF
     EQPALFAHEL RECFRQLRAK