ID   HYFF_METI4              Reviewed;         476 AA.
AC   A9QPJ1;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Hydrogenase-4 component F homolog;
DE            EC=1.-.-.-;
GN   Name=hyfF; Synonyms=hyfB; OrderedLocusNames=Minf_0513;
OS   Methylacidiphilum infernorum (isolate V4) (Methylokorus infernorum (strain
OS   V4)).
OC   Bacteria; Verrucomicrobia; Methylacidiphilae; Methylacidiphilales;
OC   Methylacidiphilaceae; Methylacidiphilum.
OX   NCBI_TaxID=481448;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate V4;
RX   PubMed=18004300; DOI=10.1038/nature06411;
RA   Dunfield P.F., Yuryev A., Senin P., Smirnova A.V., Stott M.B., Hou S.,
RA   Ly B., Saw J.H., Zhou Z., Ren Y., Wang J., Mountain B.W., Crowe M.A.,
RA   Weatherby T.M., Bodelier P.L.E., Liesack W., Feng L., Wang L., Alam M.;
RT   "Methane oxidation by an extremely acidophilic bacterium of the phylum
RT   Verrucomicrobia.";
RL   Nature 450:879-882(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate V4;
RX   PubMed=18593465; DOI=10.1186/1745-6150-3-26;
RA   Hou S., Makarova K.S., Saw J.H., Senin P., Ly B.V., Zhou Z., Ren Y.,
RA   Wang J., Galperin M.Y., Omelchenko M.V., Wolf Y.I., Yutin N., Koonin E.V.,
RA   Stott M.B., Mountain B.W., Crowe M.A., Smirnova A.V., Dunfield P.F.,
RA   Feng L., Wang L., Alam M.;
RT   "Complete genome sequence of the extremely acidophilic methanotroph isolate
RT   V4, Methylacidiphilum infernorum, a representative of the bacterial phylum
RT   Verrucomicrobia.";
RL   Biol. Direct 3:26-26(2008).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 5 family. {ECO:0000305}.
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DR   EMBL; EU223907; ABX56649.1; -; Genomic_DNA.
DR   EMBL; CP000975; ACD82571.1; -; Genomic_DNA.
DR   RefSeq; WP_012462853.1; NC_010794.1.
DR   AlphaFoldDB; A9QPJ1; -.
DR   SMR; A9QPJ1; -.
DR   STRING; 481448.Minf_0513; -.
DR   EnsemblBacteria; ACD82571; ACD82571; Minf_0513.
DR   KEGG; min:Minf_0513; -.
DR   eggNOG; COG0651; Bacteria.
DR   HOGENOM; CLU_007100_10_1_0; -.
DR   OMA; YIFIAST; -.
DR   OrthoDB; 1887859at2; -.
DR   Proteomes; UP000009149; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01437; NUOXDRDTASE4.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Oxidoreductase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..476
FT                   /note="Hydrogenase-4 component F homolog"
FT                   /id="PRO_0000401185"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        442..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   476 AA;  51800 MW;  D32E476CB04C1066 CRC64;
     MSAAAVILFP FIGILLLSQI SSYRISSWLN TLFSFLSFVG SLFLLFKKDP PGSFFLVDEL
     NIVFILLTNF IGFTTALFSQ RYIAHEIEIG HLSPPSLRFY HSMYQALLFG MNLALCSNNI
     GLMWVSIEMA TLSTVLMVGI YRTTESLEAS WKYFILGGVG IALALFGTFL FYISARPTIG
     EGLAAMAWTN LFSHAAYLDS SLVNIGFIFI LIGYGTKVGL FPLHGWLPDA HAEGPTPISA
     VLSGLLLNVA LYAILRFKIL LSANPHALQA GPLLTAMGLA SVLFAALMFY KRRDIKRLFA
     YSSIEHMGII SFAFGIGGAL ANFAGLLHMS MHSLTKSAIF FAIGYISQIK RTQKIADLSG
     LTSSHPVLGW GLVFGVLAIA GLPPMGVFMS EFLVLSSAFA RSPLLAACLA VGLITALGAL
     ILKLVQVSFG EPRGDSSPIR SLYLPMFSHF LLVFAAGVYI PPRVVEWFQH CSVLLK