ID   HYI_CAEEL               Reviewed;         262 AA.
AC   Q11185;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Putative hydroxypyruvate isomerase;
DE            EC=5.3.1.22;
GN   ORFNames=C05D11.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Catalyzes the reversible isomerization between
CC       hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate
CC       semialdehyde). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate;
CC         Xref=Rhea:RHEA:11952, ChEBI:CHEBI:17180, ChEBI:CHEBI:57978;
CC         EC=5.3.1.22;
CC   -!- SIMILARITY: Belongs to the hyi family. {ECO:0000305}.
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DR   EMBL; FO080365; CCD63194.1; -; Genomic_DNA.
DR   PIR; A88482; A88482.
DR   RefSeq; NP_498404.1; NM_066003.5.
DR   AlphaFoldDB; Q11185; -.
DR   SMR; Q11185; -.
DR   STRING; 6239.C05D11.5; -.
DR   EPD; Q11185; -.
DR   PaxDb; Q11185; -.
DR   PeptideAtlas; Q11185; -.
DR   EnsemblMetazoa; C05D11.5.1; C05D11.5.1; WBGene00015483.
DR   GeneID; 182258; -.
DR   KEGG; cel:CELE_C05D11.5; -.
DR   UCSC; C05D11.5; c. elegans.
DR   CTD; 182258; -.
DR   WormBase; C05D11.5; CE01135; WBGene00015483; -.
DR   eggNOG; KOG4518; Eukaryota.
DR   GeneTree; ENSGT00390000005462; -.
DR   HOGENOM; CLU_050006_1_1_1; -.
DR   InParanoid; Q11185; -.
DR   OMA; YVQYDIY; -.
DR   OrthoDB; 1440394at2759; -.
DR   PhylomeDB; Q11185; -.
DR   PRO; PR:Q11185; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00015483; Expressed in material anatomical entity and 5 other tissues.
DR   GO; GO:0008903; F:hydroxypyruvate isomerase activity; IBA:GO_Central.
DR   GO; GO:0046487; P:glyoxylate metabolic process; IBA:GO_Central.
DR   InterPro; IPR026040; HyI-like.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   PIRSF; PIRSF006241; HyI; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..262
FT                   /note="Putative hydroxypyruvate isomerase"
FT                   /id="PRO_0000209115"
FT   ACT_SITE        146
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q9WYP7"
FT   ACT_SITE        244
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q9WYP7"
SQ   SEQUENCE   262 AA;  29659 MW;  0B618E52BADBF7EF CRC64;
     MSGTNRVAAN LNMLFTNLPL LQRYGAAASA GFKLVEVSIP YTEPAEKLRE AADEYHLKHT
     LINAPPGNWD DGFRGLASLK SAKKEFRKSL DTAIEYAKAL GCCRVHVMAG IPKSDDDLEN
     AHQTYSENVR FAAEKFKEHK LICLIEPINK YTIPGYHLNN YEDAMDVIQM DQSNNLKIQY
     DTFHAQQING QIGAIMRKLK DYIGYIQVAQ VPNRGACDTR GEIDYHFIFD EIRSINPSWV
     IGAEYLDAKP SFNWIENMSL SF