ID   HYI_DANRE               Reviewed;         276 AA.
AC   Q7T3H9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Putative hydroxypyruvate isomerase;
DE            EC=5.3.1.22;
GN   Name=hyi; ORFNames=zgc:63850;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible isomerization between
CC       hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate
CC       semialdehyde). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate;
CC         Xref=Rhea:RHEA:11952, ChEBI:CHEBI:17180, ChEBI:CHEBI:57978;
CC         EC=5.3.1.22;
CC   -!- SIMILARITY: Belongs to the hyi family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH53111.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC053111; AAH53111.1; ALT_INIT; mRNA.
DR   RefSeq; NP_956628.1; NM_200334.1.
DR   AlphaFoldDB; Q7T3H9; -.
DR   SMR; Q7T3H9; -.
DR   STRING; 7955.ENSDARP00000044088; -.
DR   Ensembl; ENSDART00000158333; ENSDARP00000131995; ENSDARG00000030166.
DR   GeneID; 393305; -.
DR   KEGG; dre:393305; -.
DR   CTD; 81888; -.
DR   ZFIN; ZDB-GENE-040426-1273; hyi.
DR   eggNOG; KOG4518; Eukaryota.
DR   GeneTree; ENSGT00390000005462; -.
DR   InParanoid; Q7T3H9; -.
DR   OrthoDB; 1440394at2759; -.
DR   PhylomeDB; Q7T3H9; -.
DR   PRO; PR:Q7T3H9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000030166; Expressed in liver and 26 other tissues.
DR   ExpressionAtlas; Q7T3H9; baseline.
DR   GO; GO:0008903; F:hydroxypyruvate isomerase activity; IBA:GO_Central.
DR   GO; GO:0046487; P:glyoxylate metabolic process; IBA:GO_Central.
DR   InterPro; IPR026040; HyI-like.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   PIRSF; PIRSF006241; HyI; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
PE   2: Evidence at transcript level;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..276
FT                   /note="Putative hydroxypyruvate isomerase"
FT                   /id="PRO_0000289243"
FT   ACT_SITE        150
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q9WYP7"
FT   ACT_SITE        249
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q9WYP7"
SQ   SEQUENCE   276 AA;  31186 MW;  64C48FF2565F6B93 CRC64;
     MAPLKFCANI SWLFTELPEF PQRMRAAASA GFRAVEAAWL YNTDLKELKT AKEETGLEFV
     LINTPPGDAS AGDLGLAAVP GREQEFRQGL DLAVQYAKAL DCTRIHLMAG RVPAGSERCA
     LALQMEDTFV HNLKHAAGVL DKEGLLGLIE PINSRITDPR YFLHSPHQAA EILQRVDHPS
     IKMQMDIFHW QIMDGNLTHN IRRYLPMTGH IQIAQVPDRH EPDSPGELNF SFIFRLLEEL
     DYQGFIGCEY KPQGSTEAGL EWLRKYWRSR NGGERD