HYI_DROME
ID HYI_DROME Reviewed; 264 AA.
AC P36951; Q9W2W4;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Putative hydroxypyruvate isomerase;
DE EC=5.3.1.22;
DE AltName: Full=GIP-like protein;
DE AltName: Full=Transient receptor potential locus C protein;
GN Name=Gip; ORFNames=CG2227;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3118483; DOI=10.1007/bf01534486;
RA Wong F., Yuh Z.T., Schaefer E.L., Roop B.C., Ally A.H.;
RT "Overlapping transcription units in the transient receptor potential locus
RT of Drosophila melanogaster.";
RL Somat. Cell Mol. Genet. 13:661-669(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Catalyzes the reversible isomerization between
CC hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate
CC semialdehyde). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate;
CC Xref=Rhea:RHEA:11952, ChEBI:CHEBI:17180, ChEBI:CHEBI:57978;
CC EC=5.3.1.22;
CC -!- SIMILARITY: Belongs to the hyi family. {ECO:0000305}.
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DR EMBL; M18635; AAA28978.1; -; mRNA.
DR EMBL; AE014298; AAF46573.1; -; Genomic_DNA.
DR EMBL; AY071075; AAL48697.1; -; mRNA.
DR PIR; S29144; S29144.
DR RefSeq; NP_511106.1; NM_078551.4.
DR AlphaFoldDB; P36951; -.
DR SMR; P36951; -.
DR BioGRID; 58392; 12.
DR DIP; DIP-20018N; -.
DR IntAct; P36951; 2.
DR STRING; 7227.FBpp0071406; -.
DR PaxDb; P36951; -.
DR PRIDE; P36951; -.
DR DNASU; 31960; -.
DR EnsemblMetazoa; FBtr0071472; FBpp0071406; FBgn0011770.
DR GeneID; 31960; -.
DR KEGG; dme:Dmel_CG2227; -.
DR UCSC; CG2227-RA; d. melanogaster.
DR CTD; 2695; -.
DR FlyBase; FBgn0011770; Gip.
DR VEuPathDB; VectorBase:FBgn0011770; -.
DR eggNOG; KOG4518; Eukaryota.
DR GeneTree; ENSGT00390000005462; -.
DR HOGENOM; CLU_050006_1_1_1; -.
DR InParanoid; P36951; -.
DR OMA; CEYRPRA; -.
DR OrthoDB; 1440394at2759; -.
DR PhylomeDB; P36951; -.
DR BioGRID-ORCS; 31960; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Gip; fly.
DR GenomeRNAi; 31960; -.
DR PRO; PR:P36951; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0011770; Expressed in Malpighian tubule and 28 other tissues.
DR Genevisible; P36951; DM.
DR GO; GO:0005576; C:extracellular region; HDA:FlyBase.
DR GO; GO:0008903; F:hydroxypyruvate isomerase activity; ISS:FlyBase.
DR GO; GO:0046487; P:glyoxylate metabolic process; ISS:FlyBase.
DR InterPro; IPR026040; HyI-like.
DR InterPro; IPR036237; Xyl_isomerase-like_sf.
DR InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR Pfam; PF01261; AP_endonuc_2; 1.
DR PIRSF; PIRSF006241; HyI; 1.
DR SUPFAM; SSF51658; SSF51658; 1.
PE 2: Evidence at transcript level;
KW Isomerase; Reference proteome.
FT CHAIN 1..264
FT /note="Putative hydroxypyruvate isomerase"
FT /id="PRO_0000013610"
FT ACT_SITE 145
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000250|UniProtKB:Q9WYP7"
FT ACT_SITE 243
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000250|UniProtKB:Q9WYP7"
SQ SEQUENCE 264 AA; 29093 MW; D469EAF11DF629B7 CRC64;
MALKFAANLN FLFTERATSI AERIRLAHQN GFRAVEIPYP EGETSDVVSA VKETGVVVSL
VNLAFDKSDD QLRFGSTSVP GSEKLFRSQL DATIDFARQV NCGKIHLTAG LFKGGQESDY
TKTYTANLKI AADSLRASKM IGVIEPINKY AVPGYYMNSY SKAAGILADV AADNIQLLAD
LYHLQHLHGN VSKTLEEYKA LIGHFQIAQV PHRHEPDVSG ELDYGFVFKA LQEFGYDGWI
GCEYKPKTTT VEGLGWVSKL GYTL
