ID   HYI_XENLA               Reviewed;         275 AA.
AC   Q6NUD4;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Putative hydroxypyruvate isomerase;
DE            EC=5.3.1.22;
GN   Name=hyi;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible isomerization between
CC       hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate
CC       semialdehyde). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate;
CC         Xref=Rhea:RHEA:11952, ChEBI:CHEBI:17180, ChEBI:CHEBI:57978;
CC         EC=5.3.1.22;
CC   -!- SIMILARITY: Belongs to the hyi family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH68661.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC068661; AAH68661.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001084705.1; NM_001091236.1.
DR   AlphaFoldDB; Q6NUD4; -.
DR   SMR; Q6NUD4; -.
DR   DNASU; 414666; -.
DR   GeneID; 414666; -.
DR   KEGG; xla:414666; -.
DR   CTD; 414666; -.
DR   Xenbase; XB-GENE-5847302; hyi.L.
DR   OrthoDB; 1440394at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 414666; Expressed in liver and 20 other tissues.
DR   GO; GO:0008903; F:hydroxypyruvate isomerase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR026040; HyI-like.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   PIRSF; PIRSF006241; HyI; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
PE   2: Evidence at transcript level;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..275
FT                   /note="Putative hydroxypyruvate isomerase"
FT                   /id="PRO_0000289244"
FT   ACT_SITE        147
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q9WYP7"
FT   ACT_SITE        246
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q9WYP7"
SQ   SEQUENCE   275 AA;  30983 MW;  0DE84F0C3D930551 CRC64;
     MRFSANISWL FPEVPDFPGR IKAASQSGFR AVEVAWPYAT DRTLFKAALN THRMSLVLLN
     TPPGNIEAGE LGLAAVPGRQ DEFRTGLNEA VSWASDLGCD RIHIMAGRVP LGLERQFIEK
     EMEETFIENL QYAADILGQA GMVGLLEPIN SLITEPRYFL NTPQHAASIL HKVKRPNLKL
     QMDLYHWQIM GGNLTQNIKT YFPLIGHVQI AQIPHRNEPD SPGELNFMYL FDLLQDLGYQ
     GYVGCEYKPQ GDTVKGLGWM EKYLKNCDGD EDKTK