ID   HYKK_BOVIN              Reviewed;         376 AA.
AC   A5PJU6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Hydroxylysine kinase;
DE            Short=5-hydroxy-L-lysine kinase;
DE            EC=2.7.1.81;
DE   AltName: Full=Aminoglycoside phosphotransferase domain-containing protein 1;
GN   Name=HYKK; Synonyms=AGPHD1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-
CC       lysine. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine +
CC         GDP + H(+); Xref=Rhea:RHEA:19049, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:37565, ChEBI:CHEBI:57882, ChEBI:CHEBI:58189,
CC         ChEBI:CHEBI:58357; EC=2.7.1.81;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC       {ECO:0000305}.
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DR   EMBL; BC142244; AAI42245.1; -; mRNA.
DR   RefSeq; NP_001092517.1; NM_001099047.2.
DR   RefSeq; XP_005222020.1; XM_005221963.3.
DR   RefSeq; XP_005222021.1; XM_005221964.3.
DR   RefSeq; XP_005222022.1; XM_005221965.3.
DR   RefSeq; XP_010815382.1; XM_010817080.2.
DR   RefSeq; XP_010815383.1; XM_010817081.2.
DR   RefSeq; XP_015314730.1; XM_015459244.1.
DR   AlphaFoldDB; A5PJU6; -.
DR   SMR; A5PJU6; -.
DR   STRING; 9913.ENSBTAP00000002339; -.
DR   PaxDb; A5PJU6; -.
DR   PRIDE; A5PJU6; -.
DR   Ensembl; ENSBTAT00000002339; ENSBTAP00000002339; ENSBTAG00000001786.
DR   Ensembl; ENSBTAT00000067508; ENSBTAP00000072661; ENSBTAG00000001786.
DR   GeneID; 530270; -.
DR   KEGG; bta:530270; -.
DR   CTD; 123688; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001786; -.
DR   VGNC; VGNC:30013; HYKK.
DR   eggNOG; ENOG502QT7T; Eukaryota.
DR   GeneTree; ENSGT00390000011314; -.
DR   HOGENOM; CLU_042971_1_1_1; -.
DR   InParanoid; A5PJU6; -.
DR   OMA; QNFHVHI; -.
DR   OrthoDB; 1519192at2759; -.
DR   TreeFam; TF324471; -.
DR   Reactome; R-BTA-71064; Lysine catabolism.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000001786; Expressed in metanephros cortex and 105 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019202; F:amino acid kinase activity; IBA:GO_Central.
DR   GO; GO:0047992; F:hydroxylysine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Kinase; Reference proteome; Transferase.
FT   CHAIN           1..376
FT                   /note="Hydroxylysine kinase"
FT                   /id="PRO_0000326043"
FT   ACT_SITE        229
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   376 AA;  42077 MW;  F42E36FA0111F1B2 CRC64;
     MSSGDGQQSQ ALTKPSFSEV QASALVESVF GLKVSKIQPL PSYDDQNFHV CIARTKVTTD
     GPNECVLKIS NTESSKTPDL IEVQTHIIMF LRAAGFPTAS VCRTKGDNVS SLVSVDSGSE
     VKSYLVRLLT YLPGRPIAEI PIGPQLLYEI GRLAAKLDKT LEKFHHPKLS SLHRENFIWN
     LKSVPLLEKY LYALGQNRNR EIVEQVIQLF KDEVMTSLSH FRECINHGDL NDHNILIVSS
     ESAFGDAVYQ VSGILDFDDM SYGYYVFEVA ITIMYMMIES KTPIQVGGHV LAGFESVVPL
     TPVERGALFL LVCSRFCQSL VLAAYSCQLY PENEEYLMIT AKTGWKHLQQ MFDMGRKAVE
     EIWFETAKSY ESGISM