ID   HYKK_DANRE              Reviewed;         355 AA.
AC   A8WFT6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Hydroxylysine kinase;
DE            Short=5-hydroxy-L-lysine kinase;
DE            EC=2.7.1.81;
GN   Name=hykk; Synonyms=agphd1; ORFNames=zgc:171550;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larval eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-
CC       lysine. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine +
CC         GDP + H(+); Xref=Rhea:RHEA:19049, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:37565, ChEBI:CHEBI:57882, ChEBI:CHEBI:58189,
CC         ChEBI:CHEBI:58357; EC=2.7.1.81;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC       {ECO:0000305}.
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DR   EMBL; BC154451; AAI54452.1; -; mRNA.
DR   RefSeq; NP_001107059.1; NM_001113587.1.
DR   AlphaFoldDB; A8WFT6; -.
DR   SMR; A8WFT6; -.
DR   STRING; 7955.ENSDARP00000104064; -.
DR   PaxDb; A8WFT6; -.
DR   GeneID; 559560; -.
DR   KEGG; dre:559560; -.
DR   CTD; 559560; -.
DR   ZFIN; ZDB-GENE-080204-31; hykk.2.
DR   eggNOG; ENOG502QT7T; Eukaryota.
DR   InParanoid; A8WFT6; -.
DR   OrthoDB; 1519192at2759; -.
DR   PhylomeDB; A8WFT6; -.
DR   Reactome; R-DRE-71064; Lysine catabolism.
DR   PRO; PR:A8WFT6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019202; F:amino acid kinase activity; IBA:GO_Central.
DR   GO; GO:0047992; F:hydroxylysine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Kinase; Reference proteome; Transferase.
FT   CHAIN           1..355
FT                   /note="Hydroxylysine kinase"
FT                   /id="PRO_0000326046"
FT   ACT_SITE        215
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   355 AA;  40486 MW;  EF3C7F2C27D960C6 CRC64;
     MSTKESKPNL SHSQVTDVVK RLYGLTASVV RPLPSYDDQN FYVAPSEGGE FVLKVMNSAD
     SENVAVIELQ TQSMNFLHQR GLPAQTALPT LTGQLMSLEE FDCGFGTQIY LVRLLTYLPG
     TTIAKITCSP QILYDVGKMA ATLDTVLLQM EHPNTRVLQR ERFIWKLTSI PLLNQYVHVM
     DGDPVQKIVK GVIEKYQVQV MPKLPLFREC INHGDFNDHN LLVKPDGPSK YKISGILDFA
     DMSCGYFIFE LAITIMYMMI ESPTPLDVGG PVVAGWESVF PLNEAERDSL YWLVMCRFCQ
     SLVLARYTVI QQPENEEYLM ITSRKGLRHL SRLWELGKDE VERRWFQSAQ QFRQI