ID   HYKK_XENLA              Reviewed;         374 AA.
AC   Q6PB06;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Hydroxylysine kinase;
DE            Short=5-hydroxy-L-lysine kinase;
DE            EC=2.7.1.81;
GN   Name=hykk; Synonyms=agphd1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-
CC       lysine. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine +
CC         GDP + H(+); Xref=Rhea:RHEA:19049, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:37565, ChEBI:CHEBI:57882, ChEBI:CHEBI:58189,
CC         ChEBI:CHEBI:58357; EC=2.7.1.81;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC059978; AAH59978.1; -; mRNA.
DR   RefSeq; NP_001083264.1; NM_001089795.1.
DR   AlphaFoldDB; Q6PB06; -.
DR   SMR; Q6PB06; -.
DR   DNASU; 398833; -.
DR   GeneID; 398833; -.
DR   KEGG; xla:398833; -.
DR   CTD; 398833; -.
DR   Xenbase; XB-GENE-956853; hykk.L.
DR   OrthoDB; 1519192at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 398833; Expressed in kidney and 12 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0047992; F:hydroxylysine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Kinase; Reference proteome; Transferase.
FT   CHAIN           1..374
FT                   /note="Hydroxylysine kinase"
FT                   /id="PRO_0000326047"
FT   ACT_SITE        228
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   374 AA;  42262 MW;  E1B8E62728516B8A CRC64;
     MAENKHIAAL NNNKPALSED QAVQLIESLY GVKVLNIKPL PSYDDQNFYI KSCSEDPNGC
     CEYVMKITNS EDSRYGELLE AQTSVMVFLC SNGVPAQKPV FTKNGQSLSL ETIDYGSTIQ
     KQAVRLLTYL PGTPLARVVA TPEILFDIGK MAANIDKMLA ENFLHPNKTC FERGQFIWNL
     SNTSLLRKYA HAVKETELQK IIEDVITQYE TFVLPNLNCF RKCINHGDLN DHNILVEKTS
     SPGSIQEQYK VSGILDFSDM SFGYYIFELA ITIMYMMIES NDPLHAGGYV LAGFQSVIPL
     TDEEKDALFF LVNCRFSQSL VMARYSVQLC PENEEYLMIT AKTGWKHLQT LHDMGKEAVE
     KIWFETADSY VATH