ID   HYLS1_BOVIN             Reviewed;         314 AA.
AC   Q2KI52;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Centriolar and ciliogenesis-associated protein HYLS1 {ECO:0000305};
DE   AltName: Full=Hydrolethalus syndrome protein 1 homolog;
GN   Name=HYLS1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in ciliogenesis.
CC       {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96M11}. Cell
CC       projection, cilium {ECO:0000250|UniProtKB:A0A1L8ER70,
CC       ECO:0000250|UniProtKB:Q95X94}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}.
CC   -!- SIMILARITY: Belongs to the HYLS1 family. {ECO:0000305}.
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DR   EMBL; BC112767; AAI12768.1; -; mRNA.
DR   RefSeq; NP_001039904.1; NM_001046439.1.
DR   AlphaFoldDB; Q2KI52; -.
DR   STRING; 9913.ENSBTAP00000051795; -.
DR   PaxDb; Q2KI52; -.
DR   Ensembl; ENSBTAT00000053219; ENSBTAP00000051795; ENSBTAG00000010859.
DR   GeneID; 538735; -.
DR   KEGG; bta:538735; -.
DR   CTD; 219844; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010859; -.
DR   VGNC; VGNC:30014; HYLS1.
DR   eggNOG; ENOG502QVD7; Eukaryota.
DR   GeneTree; ENSGT00390000008848; -.
DR   HOGENOM; CLU_079788_0_0_1; -.
DR   InParanoid; Q2KI52; -.
DR   OMA; QKWANMD; -.
DR   TreeFam; TF336132; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000010859; Expressed in oocyte and 106 other tissues.
DR   GO; GO:0005814; C:centriole; IBA:GO_Central.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0097730; C:non-motile cilium; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR026227; HYLS1.
DR   InterPro; IPR027918; HYLS1_C_dom.
DR   Pfam; PF15311; HYLS1_C; 1.
DR   PRINTS; PR02098; HYLETHALUSS1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..314
FT                   /note="Centriolar and ciliogenesis-associated protein
FT                   HYLS1"
FT                   /id="PRO_0000284924"
FT   REGION          64..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..100
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   314 AA;  36196 MW;  21C9E18118FEC822 CRC64;
     MAQRRRSFSI GEAVEELVGP DGQKWADMDP EERMLVAAKA FPHICAGHGE GDVRREAQST
     LYDPYSKASV TSGKQPAFPA QLHHPHTESN GASEAVSETS QRLRKPVMKR KVLRRKPDGE
     VLVTDESMIS ESESGTENDM DVWDLRQRLM NLHFQEDRES PVDVSQKFSL PREYQGISQD
     QLICYLRREE MGPPAYEQDL IVASRPKSFI LPRLDQLSRN RGKVDRVARY FEYKRDWDSM
     RLPGEDHRKE LRWGIREQML CRAEAQSKPQ HIYVPNNYLV PTEKKRSALR WGVRCDLANG
     VMPKKLTSFP LFPS