ID   HYLS1_CAEEL             Reviewed;         274 AA.
AC   Q95X94;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Centriolar and ciliogenesis-associated protein hyls-1 {ECO:0000305};
DE   AltName: Full=Hydrolethalus syndrome protein 1 homolog;
GN   Name=hyls-1 {ECO:0000312|WormBase:C05C8.9a};
GN   ORFNames=C05C8.9 {ECO:0000312|WormBase:C05C8.9a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   SUBCELLULAR LOCATION, INTERACTION WITH SAS-4, FUNCTION, MUTAGENESIS OF
RP   ASP-210, AND DISRUPTION PHENOTYPE.
RX   PubMed=19656802; DOI=10.1101/gad.1810409;
RA   Dammermann A., Pemble H., Mitchell B.J., McLeod I., Yates J.R. III,
RA   Kintner C., Desai A.B., Oegema K.;
RT   "The hydrolethalus syndrome protein HYLS-1 links core centriole structure
RT   to cilia formation.";
RL   Genes Dev. 23:2046-2059(2009).
CC   -!- FUNCTION: Plays an important role in ciliogenesis (PubMed:19656802).
CC       {ECO:0000269|PubMed:19656802}.
CC   -!- SUBUNIT: Interacts with sas-4; leading to its localization into newly
CC       forming centrioles. {ECO:0000269|PubMed:19656802}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000269|PubMed:19656802}. Cell
CC       projection, cilium {ECO:0000269|PubMed:19656802}. Note=Colocalizes with
CC       sas-4 to centrioles throughout the embryonic cell cycle and in sperm
CC       (PubMed:19656802). Localizes at the base of mature
CC       cilia(PubMed:19656802). {ECO:0000269|PubMed:19656802}.
CC   -!- DISRUPTION PHENOTYPE: Embryos do not show centriole duplication
CC       defects, are viable, and develop into fertile adults, but only 10% of
CC       the normal number of ciliated neurons are observed.
CC       {ECO:0000269|PubMed:19656802}.
CC   -!- SIMILARITY: Belongs to the HYLS1 family. {ECO:0000305}.
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DR   EMBL; BX284605; CCD63094.1; -; Genomic_DNA.
DR   RefSeq; NP_504840.1; NM_072439.5.
DR   AlphaFoldDB; Q95X94; -.
DR   IntAct; Q95X94; 1.
DR   STRING; 6239.C05C8.9a.1; -.
DR   EPD; Q95X94; -.
DR   PaxDb; Q95X94; -.
DR   EnsemblMetazoa; C05C8.9a.1; C05C8.9a.1; WBGene00015466.
DR   GeneID; 179118; -.
DR   KEGG; cel:CELE_C05C8.9; -.
DR   UCSC; C05C8.9a; c. elegans.
DR   CTD; 179118; -.
DR   WormBase; C05C8.9a; CE28884; WBGene00015466; hyls-1.
DR   eggNOG; ENOG502SGJ2; Eukaryota.
DR   HOGENOM; CLU_088342_0_0_1; -.
DR   InParanoid; Q95X94; -.
DR   OMA; HRAYETC; -.
DR   OrthoDB; 1627607at2759; -.
DR   PhylomeDB; Q95X94; -.
DR   SignaLink; Q95X94; -.
DR   PRO; PR:Q95X94; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00015466; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q95X94; baseline and differential.
DR   GO; GO:0005814; C:centriole; IDA:WormBase.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0097730; C:non-motile cilium; IDA:WormBase.
DR   GO; GO:0060271; P:cilium assembly; IMP:WormBase.
DR   GO; GO:0060756; P:foraging behavior; IMP:WormBase.
DR   InterPro; IPR027918; HYLS1_C_dom.
DR   Pfam; PF15311; HYLS1_C; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..274
FT                   /note="Centriolar and ciliogenesis-associated protein hyls-
FT                   1"
FT                   /id="PRO_0000441756"
FT   REGION          156..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         210
FT                   /note="D->G: Does not alter centriole localization; Does
FT                   not alter cilium localization; Partial rescue cilia
FT                   assembly in the hyls-1 deletion mutants."
FT                   /evidence="ECO:0000269|PubMed:19656802"
SQ   SEQUENCE   274 AA;  32182 MW;  23D9ECBB2972A412 CRC64;
     MANFTTENEL EDILHQMGHH IHDKNQFATF KNEIDNLLDR ELCLSDADED VMNESLFASL
     SVDPAAQFIR QERNFPTENL NIQSPIVSRK RQGKRFIYEN VELQSDFDDE SSNEYPERNL
     LVDRAWRSIH RAMETCNGAT ETLKSISLDG SDIQERSSVD DEENIAESVS VGLSTETEQS
     ELQKSSRPEK EVWTRNVLSL EPGRAPKKYD PVTRYHFYKS EWDRHPAPGE MRRLSLRWKV
     REFMLRHDVP RLNENNEDWK ANHDKDWSPR PYID