ID   HYLS1_MACFA             Reviewed;         299 AA.
AC   Q4R2Y2;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Centriolar and ciliogenesis-associated protein HYSL1 {ECO:0000305};
DE   AltName: Full=Hydrolethalus syndrome protein 1 homolog;
GN   Name=HYLS1; ORFNames=QtsA-21349;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in ciliogenesis.
CC       {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96M11}. Cell
CC       projection, cilium {ECO:0000250|UniProtKB:A0A1L8ER70,
CC       ECO:0000250|UniProtKB:Q95X94}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}.
CC   -!- SIMILARITY: Belongs to the HYLS1 family. {ECO:0000305}.
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DR   EMBL; AB179486; BAE02537.1; -; mRNA.
DR   RefSeq; NP_001306377.1; NM_001319448.1.
DR   RefSeq; XP_005580155.2; XM_005580098.2.
DR   RefSeq; XP_015291405.1; XM_015435919.1.
DR   AlphaFoldDB; Q4R2Y2; -.
DR   STRING; 9541.XP_005580155.1; -.
DR   Ensembl; ENSMFAT00000078129; ENSMFAP00000054713; ENSMFAG00000010478.
DR   Ensembl; ENSMFAT00000091798; ENSMFAP00000052930; ENSMFAG00000010478.
DR   GeneID; 101925278; -.
DR   KEGG; mcf:101925278; -.
DR   CTD; 219844; -.
DR   VEuPathDB; HostDB:ENSMFAG00000010478; -.
DR   eggNOG; ENOG502QVD7; Eukaryota.
DR   GeneTree; ENSGT00390000008848; -.
DR   OMA; QKWANMD; -.
DR   Proteomes; UP000233100; Chromosome 14.
DR   Bgee; ENSMFAG00000010478; Expressed in thymus and 13 other tissues.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR026227; HYLS1.
DR   InterPro; IPR027918; HYLS1_C_dom.
DR   Pfam; PF15311; HYLS1_C; 1.
DR   PRINTS; PR02098; HYLETHALUSS1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..299
FT                   /note="Centriolar and ciliogenesis-associated protein
FT                   HYSL1"
FT                   /id="PRO_0000284926"
FT   MOD_RES         179
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96M11"
SQ   SEQUENCE   299 AA;  34432 MW;  4B15B1800CC883BF CRC64;
     MEELLPDRQV WANMDPEERM LAAATAFTHI CAGQGEGDVR REAQSIQYDP YSKASIAPGK
     RPTLPVQLQY PHVESNVTSE TVSEASQRLR KPVMKRKVLR RKPDGEVLVT DESIISESES
     GTENDQGLWD LRQRLMNVQF QEDKESSFDI SQKFNPPHEY QGISQDQLIC SLQREGMGSP
     AYEQDLIVAS RPKSFILPKL DQLSRNRGKT DRVARYFEYK RDWDSIRLPG EDHRKELRWG
     VREQMLCRAE PQSKPQHIYV PNNYLVPTEK KRSALRWGVR CDLANGVIPR KLPFPLSPS