HYLS1_MOUSE
ID HYLS1_MOUSE Reviewed; 307 AA.
AC Q9CXX0; Q3V2R4; Q8CI83;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Centriolar and ciliogenesis-associated protein HYLS1 {ECO:0000305};
DE AltName: Full=Hydrolethalus syndrome protein 1 homolog;
GN Name=Hyls1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15843405; DOI=10.1093/hmg/ddi157;
RA Mee L., Honkala H., Kopra O., Vesa J., Finnilae S., Visapaeae I.,
RA Sang T.-K., Jackson G.R., Salonen R., Kestilae M., Peltonen L.;
RT "Hydrolethalus syndrome is caused by a missense mutation in a novel gene
RT HYLS1.";
RL Hum. Mol. Genet. 14:1475-1488(2005).
CC -!- FUNCTION: Plays a role in ciliogenesis.
CC {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96M11}. Cell
CC projection, cilium {ECO:0000250|UniProtKB:A0A1L8ER70,
CC ECO:0000250|UniProtKB:Q95X94}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole
CC {ECO:0000250|UniProtKB:A0A1L8ER70, ECO:0000250|UniProtKB:Q95X94}.
CC -!- TISSUE SPECIFICITY: Expressed in hippocampus and dentate gyrus of 3-
CC month adult brain. {ECO:0000269|PubMed:15843405}.
CC -!- DEVELOPMENTAL STAGE: Detected at each embryonic stage, the highest
CC expression level observed at 11 dpc. {ECO:0000269|PubMed:15843405}.
CC -!- SIMILARITY: Belongs to the HYLS1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH35953.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB29044.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK013896; BAB29044.1; ALT_FRAME; mRNA.
DR EMBL; AK131639; BAE20733.1; -; mRNA.
DR EMBL; BC035953; AAH35953.1; ALT_INIT; mRNA.
DR RefSeq; NP_084038.1; NM_029762.1.
DR AlphaFoldDB; Q9CXX0; -.
DR IntAct; Q9CXX0; 1.
DR MINT; Q9CXX0; -.
DR STRING; 10090.ENSMUSP00000110762; -.
DR iPTMnet; Q9CXX0; -.
DR PhosphoSitePlus; Q9CXX0; -.
DR PaxDb; Q9CXX0; -.
DR PRIDE; Q9CXX0; -.
DR ProteomicsDB; 273297; -.
DR GeneID; 76832; -.
DR KEGG; mmu:76832; -.
DR UCSC; uc009oti.2; mouse.
DR CTD; 219844; -.
DR MGI; MGI:1924082; Hyls1.
DR eggNOG; ENOG502QVD7; Eukaryota.
DR InParanoid; Q9CXX0; -.
DR TreeFam; TF336132; -.
DR BioGRID-ORCS; 76832; 10 hits in 74 CRISPR screens.
DR ChiTaRS; Hyls1; mouse.
DR PRO; PR:Q9CXX0; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9CXX0; protein.
DR GO; GO:0005814; C:centriole; IBA:GO_Central.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0097730; C:non-motile cilium; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR InterPro; IPR026227; HYLS1.
DR InterPro; IPR027918; HYLS1_C_dom.
DR Pfam; PF15311; HYLS1_C; 1.
DR PRINTS; PR02098; HYLETHALUSS1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..307
FT /note="Centriolar and ciliogenesis-associated protein
FT HYLS1"
FT /id="PRO_0000284927"
FT REGION 47..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 307 AA; 35141 MW; 1F7D5A46BA95B813 CRC64;
MAEKRQAYSV PEAMKQLIGP GGQKWANMDP EERMLAAATA FTRICAGQGE GDSRREAQAG
QYDPYSKASV TPGKRPALPM HLHFPHTASR VTSSTVSETS QKCRKPVMKR KVLRRKPDGE
VLVTDESVIS ECESGTESDL GLWDLRHRFM NLQFQEGTES PVVTSQKFNL PCEYQGISQE
DQLICYLQRE EMDPPVYEQD LIVASRPKSF ILPRLDQLSR NRGKIDRVAR YFEYKRDWDS
MRFPGEDHRK ELRWSVRGQM LSRTEPPSKP QHVYVPNNYL VPLRWGVRCD LANGVMPKKL
PFPLSPS
