HYM1_YEAST
ID HYM1_YEAST Reviewed; 399 AA.
AC P32464; D6VX11;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Protein HYM1;
GN Name=HYM1; OrderedLocusNames=YKL189W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=S288c / GRF88;
RX PubMed=8394042; DOI=10.1002/yea.320090612;
RA Cheret G., Mattheakis L.C., Sor F.;
RT "DNA sequence analysis of the YCN2 region of chromosome XI in Saccharomyces
RT cerevisiae.";
RL Yeast 9:661-667(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8154185; DOI=10.1002/yea.320091208;
RA Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J.,
RA Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W.;
RT "Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI
RT from Saccharomyces cerevisiae reveals 23 open reading frames including the
RT FAS1 gene.";
RL Yeast 9:1343-1348(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP GENE NAME.
RX PubMed=10655212; DOI=10.1093/genetics/154.2.573;
RA Dorland S., Deegenaars M.L., Stillman D.J.;
RT "Roles for the Saccharomyces cerevisiae SDS3, CBK1 and HYM1 genes in
RT transcriptional repression by SIN3.";
RL Genetics 154:573-586(2000).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- INTERACTION:
CC P32464; P38692: KIC1; NbExp=4; IntAct=EBI-8859, EBI-12253;
CC P32464; Q08817: SOG2; NbExp=3; IntAct=EBI-8859, EBI-30849;
CC -!- MISCELLANEOUS: Present with 1280 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the Mo25 family. {ECO:0000305}.
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DR EMBL; X69765; CAA49422.1; -; Genomic_DNA.
DR EMBL; X74151; CAA52249.1; -; Genomic_DNA.
DR EMBL; Z28189; CAA82032.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA08977.1; -; Genomic_DNA.
DR PIR; S34681; S34681.
DR RefSeq; NP_012732.1; NM_001179755.1.
DR AlphaFoldDB; P32464; -.
DR SMR; P32464; -.
DR BioGRID; 33933; 77.
DR DIP; DIP-5425N; -.
DR IntAct; P32464; 17.
DR MINT; P32464; -.
DR STRING; 4932.YKL189W; -.
DR iPTMnet; P32464; -.
DR MaxQB; P32464; -.
DR PaxDb; P32464; -.
DR PRIDE; P32464; -.
DR EnsemblFungi; YKL189W_mRNA; YKL189W; YKL189W.
DR GeneID; 853646; -.
DR KEGG; sce:YKL189W; -.
DR SGD; S000001672; HYM1.
DR VEuPathDB; FungiDB:YKL189W; -.
DR eggNOG; KOG1566; Eukaryota.
DR GeneTree; ENSGT00390000004360; -.
DR HOGENOM; CLU_035755_0_0_1; -.
DR InParanoid; P32464; -.
DR OMA; HLKLCMN; -.
DR BioCyc; YEAST:G3O-31952-MON; -.
DR Reactome; R-SCE-6798695; Neutrophil degranulation.
DR PRO; PR:P32464; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P32464; protein.
DR GO; GO:0005933; C:cellular bud; IDA:SGD.
DR GO; GO:0000131; C:incipient cellular bud site; IDA:SGD.
DR GO; GO:0043332; C:mating projection tip; IDA:SGD.
DR GO; GO:0044732; C:mitotic spindle pole body; IDA:CACAO.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IBA:GO_Central.
DR GO; GO:0007118; P:budding cell apical bud growth; IMP:SGD.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:SGD.
DR GO; GO:0000920; P:septum digestion after cytokinesis; IMP:SGD.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013878; Mo25.
DR PANTHER; PTHR10182; PTHR10182; 1.
DR Pfam; PF08569; Mo25; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..399
FT /note="Protein HYM1"
FT /id="PRO_0000209836"
FT REGION 363..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 399 AA; 45853 MW; F48860754C892BA9 CRC64;
MFKKYKNQDL DMAFWWKKNP KTPSDYARLI IEQLNKFSSP SLTQDNKRKV QEECTKYLIG
TKHFIVGDTD PHPTPEAIDE LYTAMHRADV FYELLLHFVD LEFEARRECM LIFSICLGYS
KDNKFVTVDY LVSQPKTISL MLRTAEVALQ QKGCQDIFLT VGNMIIECIK YEQLCRIILK
DPQLWKFFEF AKLGNFEIST ESLQILSAAF TAHPKLVSKE FFSNEINIIR FIKCINKLMA
HGSYVTKRQS TKLLASLIVI RSNNALMNIY INSPENLKLI MTLMTDKSKN LQLEAFNVFK
VMVANPRKSK PVFDILVKNR DKLLTYFKTF GLDSQDSTFL DEREFIVQEI DSLPRIISST
TEVSNNNASS SNVASITSPS SVMNNQSSIL THSTSPDSR
