ID   HYP1_AGABI              Reviewed;         112 AA.
AC   P49072;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Hydrophobin-1;
DE   AltName: Full=Hydrophobin-A;
DE   Flags: Precursor;
GN   Name=hypA; Synonyms=abh1;
OS   Agaricus bisporus (White button mushroom).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricaceae; Agaricus.
OX   NCBI_TaxID=5341;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=Horst H39;
RX   PubMed=8632464; DOI=10.1006/jmbi.1996.0219;
RA   de Groot P.W.J., Schaap P.J., Visser J., van Griensven L.J.L.D.;
RT   "The Agaricus bisporus hypA gene encodes a hydrophobin and specifically
RT   accumulates in peel tissue of mushroom caps during fruit body
RT   development.";
RL   J. Mol. Biol. 257:1008-1018(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Horst U3;
RX   PubMed=8704971; DOI=10.1099/13500872-142-5-1321;
RA   Lugones L.G., Bosscher J.S., Scholtmeyer K., de Vries O.M.H.,
RA   Wessels J.G.H.;
RT   "An abundant hydrophobin (ABH1) forms hydrophobic rodlet layers in Agaricus
RT   bisporus fruiting bodies.";
RL   Microbiology 142:1321-1329(1996).
CC   -!- FUNCTION: Forms hydrophobic rodlet layers.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall.
CC   -!- DEVELOPMENTAL STAGE: Expressed in fruiting bodies.
CC   -!- SIMILARITY: Belongs to the fungal hydrophobin family. {ECO:0000305}.
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DR   EMBL; X89242; CAA61530.1; -; mRNA.
DR   EMBL; X90818; CAA62331.1; -; Genomic_DNA.
DR   EMBL; X92861; CAA63447.1; -; Genomic_DNA.
DR   PIR; S68584; S68584.
DR   AlphaFoldDB; P49072; -.
DR   SMR; P49072; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0009277; C:fungal-type cell wall; IEA:InterPro.
DR   GO; GO:0005199; F:structural constituent of cell wall; IEA:InterPro.
DR   InterPro; IPR001338; Hydrophobin.
DR   InterPro; IPR019778; Hydrophobin_CS.
DR   Pfam; PF01185; Hydrophobin; 1.
DR   SMART; SM00075; HYDRO; 1.
DR   PROSITE; PS00956; HYDROPHOBIN; 1.
PE   2: Evidence at transcript level;
KW   Cell wall; Disulfide bond; Fruiting body; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..112
FT                   /note="Hydrophobin-1"
FT                   /id="PRO_0000013500"
FT   DISULFID        32..90
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..84
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..71
FT                   /evidence="ECO:0000250"
FT   DISULFID        91..105
FT                   /evidence="ECO:0000250"
FT   CONFLICT        40..41
FT                   /note="CD -> Y (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   112 AA;  11190 MW;  F7647C12826FF6E1 CRC64;
     MISRVLVAAL VALPALVTAT PAPGKPKASS QCDVGEIHCC DTQQTPDHTS AAASGLLGVP
     INLGAFLGFD CTPISVLGVG GNNCAAQPVC CTGNQFTALI NALDCSPVNV NL