ID   HYP2_TAROF              Reviewed;          35 AA.
AC   C0HKQ4;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2017, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Peptide ToHyp2 {ECO:0000303|PubMed:26259198};
OS   Taraxacum officinale (Common dandelion) (Leontodon taraxacum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC   Crepidinae; Taraxacum.
OX   NCBI_TaxID=50225 {ECO:0000303|PubMed:26259198};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, IDENTIFICATION BY MASS
RP   SPECTROMETRY, GLYCOSYLATION, AND HYDROXYLATION AT PRO-5; PRO-9; PRO-10;
RP   PRO-12; PRO-16; PRO-20; PRO-31 AND PRO-35.
RC   TISSUE=Flower {ECO:0000303|PubMed:26259198};
RX   PubMed=26259198; DOI=10.1016/j.plantsci.2015.07.002;
RA   Astafieva A.A., Enyenihi A.A., Rogozhin E.A., Kozlov S.A., Grishin E.V.,
RA   Odintsova T.I., Zubarev R.A., Egorov T.A.;
RT   "Novel proline-hydroxyproline glycopeptides from the dandelion (Taraxacum
RT   officinale Wigg.) flowers: de novo sequencing and biological activity.";
RL   Plant Sci. 238:323-329(2015).
CC   -!- FUNCTION: Antimicrobial peptide. Inhibits elongation of hyphae in
CC       B.sorokiniana (IC(50)=3.8 uM) but has no effect on this process or on
CC       germination of conidia in a panel of other phytopathogenic fungi. At
CC       concentrations above 10 uM, has antibacterial activity.
CC       {ECO:0000269|PubMed:26259198}.
CC   -!- PTM: O-glycosylated; contains pentose side chains at some or all of the
CC       hydroxyproline residues. Glycosylation is required for full antifungal
CC       activity. {ECO:0000269|PubMed:26259198}.
CC   -!- MASS SPECTROMETRY: Mass=4350.7; Method=MALDI; Note=Glycosylated.;
CC       Evidence={ECO:0000269|PubMed:26259198};
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DR   AlphaFoldDB; C0HKQ4; -.
DR   GO; GO:0042742; P:defense response to bacterium; IDA:UniProtKB.
DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide;
KW   Glycoprotein; Hydroxylation; Plant defense.
FT   PEPTIDE         1..35
FT                   /note="Peptide ToHyp2"
FT                   /evidence="ECO:0000269|PubMed:26259198"
FT                   /id="PRO_0000441220"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..30
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         5
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:26259198"
FT   MOD_RES         9
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:26259198"
FT   MOD_RES         10
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:26259198"
FT   MOD_RES         12
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:26259198"
FT   MOD_RES         16
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:26259198"
FT   MOD_RES         20
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:26259198"
FT   MOD_RES         31
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:26259198"
FT   MOD_RES         35
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:26259198"
SQ   SEQUENCE   35 AA;  3564 MW;  21DC18B037585BE5 CRC64;
     LPKPPLLPPP VPGLAPGLPP LPVPDPVPHP PKKPP