ID   HYPAA_POMPR             Reviewed;          30 AA.
AC   P58445;
DT   05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   05-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Cyclotide hypa-A;
OS   Pombalia parviflor (Violetilla) (Hybanthus parviflorus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Violaceae; Pombalia.
OX   NCBI_TaxID=179672;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RX   PubMed=11524112; DOI=10.1016/s0031-9422(01)00173-x;
RA   Broussalis A.M., Goeransson U., Coussio J.D., Ferraro G., Martino V.,
RA   Claeson P.;
RT   "First cyclotide from Hybanthus (Violaceae).";
RL   Phytochemistry 58:47-51(2001).
CC   -!- FUNCTION: Probably participates in a plant defense mechanism.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC   -!- PTM: This is a cyclic peptide.
CC   -!- MASS SPECTROMETRY: Mass=3143; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:11524112};
CC   -!- SIMILARITY: Belongs to the cyclotide family. Bracelet subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00395}.
CC   -!- CAUTION: This peptide is cyclic. The start position was chosen by
CC       similarity to OAK1 (kalata-B1) for which the DNA sequence is known.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P58445; -.
DR   SMR; P58445; -.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR005535; Cyclotide.
DR   InterPro; IPR012323; Cyclotide_bracelet_CS.
DR   InterPro; IPR036146; Cyclotide_sf.
DR   Pfam; PF03784; Cyclotide; 1.
DR   PIRSF; PIRSF037891; Cycloviolacin; 1.
DR   SUPFAM; SSF57038; SSF57038; 1.
DR   PROSITE; PS51052; CYCLOTIDE; 1.
DR   PROSITE; PS60008; CYCLOTIDE_BRACELET; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Knottin; Plant defense.
FT   PEPTIDE         1..30
FT                   /note="Cyclotide hypa-A"
FT                   /id="PRO_0000043622"
FT   DISULFID        4..21
FT   DISULFID        8..23
FT   DISULFID        13..28
FT   CROSSLNK        1..30
FT                   /note="Cyclopeptide (Gly-Asn)"
SQ   SEQUENCE   30 AA;  3168 MW;  5A26DAD5626B9FAF CRC64;
     GIPCAESCVY IPCTITALLG CSCKNKVCYN