ID   HYPA_ARTBC              Reviewed;         139 AA.
AC   D4ARW0;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Hydrophobin A {ECO:0000303|PubMed:22408226};
DE   Flags: Precursor;
GN   Name=HYPA; ORFNames=ARB_06975 {ECO:0000312|EMBL:EFE34024.1};
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371;
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, DISRUPTION
RP   PHENOTYPE, AND FUNCTION.
RX   PubMed=22408226; DOI=10.1128/ec.00037-12;
RA   Heddergott C., Bruns S., Nietzsche S., Leonhardt I., Kurzai O.,
RA   Kniemeyer O., Brakhage A.A.;
RT   "The Arthroderma benhamiae hydrophobin HypA mediates hydrophobicity and
RT   influences recognition by human immune effector cells.";
RL   Eukaryot. Cell 11:673-682(2012).
CC   -!- FUNCTION: Contributes to surface hydrophobicity, which is important for
CC       processes such as association of hyphae in reproductive structures,
CC       dispersal of aerial spores and adhesion of pathogens to host
CC       structures. Prevents recognition by the cellular immune defense system.
CC       {ECO:0000269|PubMed:22408226}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC       {ECO:0000269|PubMed:22408226}.
CC   -!- DISRUPTION PHENOTYPE: Leads to a 'wettable' phenotype with drops of
CC       water attaching to the mycelium, whereas water drops off the wild-type
CC       colonies. Conidia show a strongly reduced tendency to float at the
CC       water-air interface of conidial suspensions. Triggers an increased
CC       activation of human neutrophil granulocytes and dendritic cells,
CC       characterized by an increased release of the immune mediators
CC       interleukin-6 (IL-6), IL-8, IL-10, and tumor necrosis factor alpha
CC       (TNF-alpha). {ECO:0000269|PubMed:22408226}.
CC   -!- SIMILARITY: Belongs to the fungal hydrophobin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ABSU01000007; EFE34024.1; -; Genomic_DNA.
DR   RefSeq; XP_003014413.1; XM_003014367.1.
DR   AlphaFoldDB; D4ARW0; -.
DR   EnsemblFungi; EFE34024; EFE34024; ARB_06975.
DR   GeneID; 9520465; -.
DR   KEGG; abe:ARB_06975; -.
DR   eggNOG; ENOG502T10M; Eukaryota.
DR   HOGENOM; CLU_106380_1_0_1; -.
DR   OMA; NCKTQVS; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0009277; C:fungal-type cell wall; IEA:InterPro.
DR   GO; GO:0005199; F:structural constituent of cell wall; IEA:InterPro.
DR   InterPro; IPR001338; Hydrophobin.
DR   InterPro; IPR019778; Hydrophobin_CS.
DR   Pfam; PF01185; Hydrophobin; 1.
DR   SMART; SM00075; HYDRO; 1.
DR   PROSITE; PS00956; HYDROPHOBIN; 1.
PE   1: Evidence at protein level;
KW   Cell wall; Disulfide bond; Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..139
FT                   /note="Hydrophobin A"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000431985"
FT   DISULFID        45..113
FT                   /evidence="ECO:0000250|UniProtKB:Q04571"
FT   DISULFID        53..107
FT                   /evidence="ECO:0000250|UniProtKB:Q04571"
FT   DISULFID        54..88
FT                   /evidence="ECO:0000250|UniProtKB:Q04571"
FT   DISULFID        114..133
FT                   /evidence="ECO:0000250|UniProtKB:Q04571"
SQ   SEQUENCE   139 AA;  14373 MW;  7FF596C00154A471 CRC64;
     MKFSIAAAVL ALASAVVAHP GAGYVSTPEK EANFQQNFQK FVTACGNGNQ VSCCNTETKK
     VGAPLTAGGL IPILDNINLE DFSLLKGCSK VDVAAVIGVQ DLLNSNCKTQ VSCCKVGDTN
     QVGLVNANVD LKCAAQNII