ID   HYPA_HELHP              Reviewed;         118 AA.
AC   Q7VI03;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Hydrogenase maturation factor HypA {ECO:0000255|HAMAP-Rule:MF_00213};
GN   Name=hypA {ECO:0000255|HAMAP-Rule:MF_00213}; OrderedLocusNames=HH_0808;
OS   Helicobacter hepaticus (strain ATCC 51449 / 3B1).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=235279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51449 / 3B1;
RX   PubMed=12810954; DOI=10.1073/pnas.1332093100;
RA   Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M.,
RA   Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R.,
RA   Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B.,
RA   Shen Z., Weber J., Frosch M., Fox J.G.;
RT   "The complete genome sequence of the carcinogenic bacterium Helicobacter
RT   hepaticus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 51449 / 3B1;
RX   PubMed=17975083; DOI=10.1099/mic.0.2007/010520-0;
RA   Benoit S.L., Zbell A.L., Maier R.J.;
RT   "Nickel enzyme maturation in Helicobacter hepaticus: roles of accessory
RT   proteins in hydrogenase and urease activities.";
RL   Microbiology 153:3748-3756(2007).
RN   [3]
RP   REVIEW ON VIRULENCE OF H.PYLORI.
RX   PubMed=17313591; DOI=10.1111/j.1574-6968.2007.00648.x;
RA   Clyne M., Dolan B., Reeves E.P.;
RT   "Bacterial factors that mediate colonization of the stomach and virulence
RT   of Helicobacter pylori.";
RL   FEMS Microbiol. Lett. 268:135-143(2007).
CC   -!- FUNCTION: Involved in the maturation of [NiFe] hydrogenases. Required
CC       for nickel insertion into the metal center of the hydrogenase.
CC       {ECO:0000255|HAMAP-Rule:MF_00213}.
CC   -!- DISRUPTION PHENOTYPE: Cells do not produce hydrogenase or urease;
CC       addition of Ni(2+) to cell cultures compensates only poorly for this
CC       loss of function. Normal amounts of apourease are produced by the
CC       cells. {ECO:0000269|PubMed:17975083}.
CC   -!- SIMILARITY: Belongs to the HypA/HybF family. {ECO:0000255|HAMAP-
CC       Rule:MF_00213}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP77405.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE017125; AAP77405.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_034365597.1; NC_004917.1.
DR   AlphaFoldDB; Q7VI03; -.
DR   SMR; Q7VI03; -.
DR   STRING; 235279.HH_0808; -.
DR   PRIDE; Q7VI03; -.
DR   EnsemblBacteria; AAP77405; AAP77405; HH_0808.
DR   KEGG; hhe:HH_0808; -.
DR   eggNOG; COG0375; Bacteria.
DR   HOGENOM; CLU_126929_6_0_7; -.
DR   OMA; DCHQESE; -.
DR   OrthoDB; 1995603at2; -.
DR   Proteomes; UP000002495; Chromosome.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051604; P:protein maturation; IEA:InterPro.
DR   HAMAP; MF_00213; HypA_HybF; 1.
DR   InterPro; IPR000688; HypA/HybF.
DR   PANTHER; PTHR34535; PTHR34535; 1.
DR   Pfam; PF01155; HypA; 1.
DR   PIRSF; PIRSF004761; Hydrgn_mat_HypA; 1.
DR   TIGRFAMs; TIGR00100; hypA; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Nickel; Reference proteome; Virulence; Zinc.
FT   CHAIN           1..118
FT                   /note="Hydrogenase maturation factor HypA"
FT                   /id="PRO_0000129041"
FT   BINDING         2
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT   BINDING         74
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT   BINDING         77
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT   BINDING         91
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT   BINDING         94
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
SQ   SEQUENCE   118 AA;  13054 MW;  36E2DAFD6091D1AE CRC64;
     MHEYSIVASL IQMCESHAKE HNAASIAKVC IAVGERSGVD SALVKSAFET FRLDSPLCQN
     TILEIQSQSV ELECRDCGHY FQAQNLTYST CPQCQSHNVI IAKGKELHLL SLELDIQS