HYPA_HELPJ
ID HYPA_HELPJ Reviewed; 117 AA.
AC P0A0U5; O25539;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Hydrogenase maturation factor HypA {ECO:0000255|HAMAP-Rule:MF_00213};
GN Name=hypA {ECO:0000255|HAMAP-Rule:MF_00213}; OrderedLocusNames=jhp_0803;
OS Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J99 / ATCC 700824;
RX PubMed=9923682; DOI=10.1038/16495;
RA Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT "Genomic sequence comparison of two unrelated isolates of the human gastric
RT pathogen Helicobacter pylori.";
RL Nature 397:176-180(1999).
CC -!- FUNCTION: Involved in the maturation of [NiFe] hydrogenases. Required
CC for nickel insertion into the metal center of the hydrogenase.
CC {ECO:0000255|HAMAP-Rule:MF_00213}.
CC -!- SIMILARITY: Belongs to the HypA/HybF family. {ECO:0000255|HAMAP-
CC Rule:MF_00213, ECO:0000305}.
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DR EMBL; AE001439; AAD06365.1; -; Genomic_DNA.
DR PIR; E64628; E64628.
DR RefSeq; WP_000545280.1; NZ_CP011330.1.
DR PDB; 6G81; NMR; -; A=1-117.
DR PDBsum; 6G81; -.
DR AlphaFoldDB; P0A0U5; -.
DR BMRB; P0A0U5; -.
DR SMR; P0A0U5; -.
DR STRING; 85963.jhp_0803; -.
DR EnsemblBacteria; AAD06365; AAD06365; jhp_0803.
DR KEGG; hpj:jhp_0803; -.
DR PATRIC; fig|85963.30.peg.169; -.
DR eggNOG; COG0375; Bacteria.
DR OMA; DCHQESE; -.
DR Proteomes; UP000000804; Chromosome.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051604; P:protein maturation; IEA:InterPro.
DR HAMAP; MF_00213; HypA_HybF; 1.
DR InterPro; IPR020538; Hydgase_Ni_incorp_HypA/HybF_CS.
DR InterPro; IPR000688; HypA/HybF.
DR PANTHER; PTHR34535; PTHR34535; 1.
DR Pfam; PF01155; HypA; 1.
DR PIRSF; PIRSF004761; Hydrgn_mat_HypA; 1.
DR TIGRFAMs; TIGR00100; hypA; 1.
DR PROSITE; PS01249; HYPA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Metal-binding; Nickel; Zinc.
FT CHAIN 1..117
FT /note="Hydrogenase maturation factor HypA"
FT /id="PRO_0000129043"
FT BINDING 2
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT BINDING 74
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT BINDING 77
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT BINDING 91
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT BINDING 94
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT HELIX 3..20
FT /evidence="ECO:0007829|PDB:6G81"
FT STRAND 23..34
FT /evidence="ECO:0007829|PDB:6G81"
FT HELIX 41..52
FT /evidence="ECO:0007829|PDB:6G81"
FT TURN 56..60
FT /evidence="ECO:0007829|PDB:6G81"
FT STRAND 62..68
FT /evidence="ECO:0007829|PDB:6G81"
FT STRAND 71..74
FT /evidence="ECO:0007829|PDB:6G81"
FT STRAND 92..94
FT /evidence="ECO:0007829|PDB:6G81"
FT STRAND 99..106
FT /evidence="ECO:0007829|PDB:6G81"
FT STRAND 108..116
FT /evidence="ECO:0007829|PDB:6G81"
SQ SEQUENCE 117 AA; 13202 MW; BA67A69E2EC35506 CRC64;
MHEYSVVSSL IALCEEHAKK NQAHKIERVV VGIGERSAMD KSLFVSAFET FREESLVCKD
AILDIVDEKV ELECKDCSHV FKPNALDYGV CEKCHSKNVI ITQGNEMRLL SLEMLAE
