HYPA_PYRAB
ID HYPA_PYRAB Reviewed; 139 AA.
AC Q9V148; G8ZJ46;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Hydrogenase maturation factor HypA {ECO:0000255|HAMAP-Rule:MF_00213};
GN Name=hypA {ECO:0000255|HAMAP-Rule:MF_00213}; OrderedLocusNames=PYRAB05810;
GN ORFNames=PAB0399;
OS Pyrococcus abyssi (strain GE5 / Orsay).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=272844;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE5 / Orsay;
RX PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA Weissenbach J., Zivanovic Y., Forterre P.;
RT "An integrated analysis of the genome of the hyperthermophilic archaeon
RT Pyrococcus abyssi.";
RL Mol. Microbiol. 47:1495-1512(2003).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=GE5 / Orsay;
RX PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA Gao J., Wang J.;
RT "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT Pyrococcus furiosus DSM 3638.";
RL Curr. Microbiol. 64:118-129(2012).
CC -!- FUNCTION: Involved in the maturation of [NiFe] hydrogenases. Required
CC for nickel insertion into the metal center of the hydrogenase.
CC {ECO:0000255|HAMAP-Rule:MF_00213}.
CC -!- SIMILARITY: Belongs to the HypA/HybF family. {ECO:0000255|HAMAP-
CC Rule:MF_00213, ECO:0000305}.
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DR EMBL; AJ248284; CAB49503.1; -; Genomic_DNA.
DR EMBL; HE613800; CCE69973.1; -; Genomic_DNA.
DR PIR; H75177; H75177.
DR RefSeq; WP_010867705.1; NC_000868.1.
DR AlphaFoldDB; Q9V148; -.
DR SMR; Q9V148; -.
DR STRING; 272844.PAB0399; -.
DR EnsemblBacteria; CAB49503; CAB49503; PAB0399.
DR GeneID; 1495486; -.
DR KEGG; pab:PAB0399; -.
DR PATRIC; fig|272844.11.peg.619; -.
DR eggNOG; arCOG04426; Archaea.
DR HOGENOM; CLU_126929_2_0_2; -.
DR OMA; EDIHFIP; -.
DR OrthoDB; 109617at2157; -.
DR PhylomeDB; Q9V148; -.
DR Proteomes; UP000000810; Chromosome.
DR Proteomes; UP000009139; Chromosome.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051604; P:protein maturation; IEA:InterPro.
DR HAMAP; MF_00213; HypA_HybF; 1.
DR InterPro; IPR020538; Hydgase_Ni_incorp_HypA/HybF_CS.
DR InterPro; IPR000688; HypA/HybF.
DR PANTHER; PTHR34535; PTHR34535; 1.
DR Pfam; PF01155; HypA; 1.
DR PIRSF; PIRSF004761; Hydrgn_mat_HypA; 1.
DR PROSITE; PS01249; HYPA; 1.
PE 3: Inferred from homology;
KW Metal-binding; Nickel; Zinc.
FT CHAIN 1..139
FT /note="Hydrogenase maturation factor HypA"
FT /id="PRO_0000129082"
FT BINDING 2
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT BINDING 73
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT BINDING 76
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT BINDING 110
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT BINDING 113
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
SQ SEQUENCE 139 AA; 15753 MW; 7FD7292CB9127C7B CRC64;
MHEWALADAI VRTALDYAQK ENASKILAIK VVLGELQDVN AEVVEFAMKE LLRGTIGEGA
EIIFEEEEAV FRCRNCGHEW KLKEVKDKLD ERIREDIHFI PEVVHAFISC PNCGSHDFEV
VKGRGVYIAG IKIEKEEGE
