ID   HYPA_SALTY              Reviewed;         118 AA.
AC   P64419; Q8XGG9;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Hydrogenase maturation factor HypA {ECO:0000255|HAMAP-Rule:MF_00213};
GN   Name=hypA {ECO:0000255|HAMAP-Rule:MF_00213}; OrderedLocusNames=STM2854;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Involved in the maturation of [NiFe] hydrogenases. Required
CC       for nickel insertion into the metal center of the hydrogenase.
CC       {ECO:0000255|HAMAP-Rule:MF_00213}.
CC   -!- SIMILARITY: Belongs to the HypA/HybF family. {ECO:0000255|HAMAP-
CC       Rule:MF_00213}.
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DR   EMBL; AE006468; AAL21734.1; -; Genomic_DNA.
DR   RefSeq; NP_461775.1; NC_003197.2.
DR   RefSeq; WP_000544461.1; NC_003197.2.
DR   AlphaFoldDB; P64419; -.
DR   SMR; P64419; -.
DR   STRING; 99287.STM2854; -.
DR   PaxDb; P64419; -.
DR   EnsemblBacteria; AAL21734; AAL21734; STM2854.
DR   GeneID; 1254377; -.
DR   KEGG; stm:STM2854; -.
DR   PATRIC; fig|99287.12.peg.3010; -.
DR   HOGENOM; CLU_126929_0_0_6; -.
DR   OMA; EEQQAEC; -.
DR   PhylomeDB; P64419; -.
DR   BioCyc; SENT99287:STM2854-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0016151; F:nickel cation binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR   GO; GO:0051604; P:protein maturation; IBA:GO_Central.
DR   HAMAP; MF_00213; HypA_HybF; 1.
DR   InterPro; IPR020538; Hydgase_Ni_incorp_HypA/HybF_CS.
DR   InterPro; IPR000688; HypA/HybF.
DR   PANTHER; PTHR34535; PTHR34535; 1.
DR   Pfam; PF01155; HypA; 1.
DR   PIRSF; PIRSF004761; Hydrgn_mat_HypA; 1.
DR   TIGRFAMs; TIGR00100; hypA; 1.
DR   PROSITE; PS01249; HYPA; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Nickel; Reference proteome; Zinc.
FT   CHAIN           1..118
FT                   /note="Hydrogenase maturation factor HypA"
FT                   /id="PRO_0000129061"
FT   BINDING         2
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT   BINDING         73
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT   BINDING         76
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT   BINDING         90
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT   BINDING         93
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
SQ   SEQUENCE   118 AA;  13485 MW;  3FF9D65D0C4B7A7F CRC64;
     MHEITLCQRA LELIEQQASA YGAKRVTAVW IKIGAFSCVE TSALSFCFDL VCRGTIAEGC
     KLHLEEQEAE CWCEHCQQYV TLLTHRVRRC PQCHSDTLRI VADDGLQIRR IEIDETED