ID   HYPA_SYNP6              Reviewed;         112 AA.
AC   P94160;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Hydrogenase maturation factor HypA {ECO:0000255|HAMAP-Rule:MF_00213};
GN   Name=hypA {ECO:0000255|HAMAP-Rule:MF_00213}; OrderedLocusNames=syc1557_d;
OS   Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis
OS   nidulans).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=269084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1402-1;
RX   PubMed=8843154; DOI=10.1016/0014-5793(96)00936-2;
RA   Boison G., Schmitz O., Mikheeva L.E., Shestakov S.V., Bothe H.;
RT   "Cloning, molecular analysis and insertional mutagenesis of the
RT   bidirectional hydrogenase genes from the cyanobacterium Anacystis
RT   nidulans.";
RL   FEBS Lett. 394:153-158(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27144 / PCC 6301 / SAUG 1402/1;
RX   PubMed=17211581; DOI=10.1007/s11120-006-9122-4;
RA   Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M.,
RA   Kanehisa M., Omata T., Sugiura M., Sugita M.;
RT   "Complete nucleotide sequence of the freshwater unicellular cyanobacterium
RT   Synechococcus elongatus PCC 6301 chromosome: gene content and
RT   organization.";
RL   Photosyn. Res. 93:55-67(2007).
CC   -!- FUNCTION: Involved in the maturation of [NiFe] hydrogenases. Required
CC       for nickel insertion into the metal center of the hydrogenase.
CC       {ECO:0000255|HAMAP-Rule:MF_00213}.
CC   -!- SIMILARITY: Belongs to the HypA/HybF family. {ECO:0000255|HAMAP-
CC       Rule:MF_00213, ECO:0000305}.
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DR   EMBL; X97797; CAA66384.1; -; Genomic_DNA.
DR   EMBL; AP008231; BAD79747.1; -; Genomic_DNA.
DR   RefSeq; WP_011243867.1; NC_006576.1.
DR   AlphaFoldDB; P94160; -.
DR   SMR; P94160; -.
DR   STRING; 269084.syc1557_d; -.
DR   EnsemblBacteria; BAD79747; BAD79747; syc1557_d.
DR   KEGG; syc:syc1557_d; -.
DR   eggNOG; COG0375; Bacteria.
DR   OMA; ILLCPCG; -.
DR   Proteomes; UP000001175; Chromosome.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051604; P:protein maturation; IEA:InterPro.
DR   HAMAP; MF_00213; HypA_HybF; 1.
DR   InterPro; IPR020538; Hydgase_Ni_incorp_HypA/HybF_CS.
DR   InterPro; IPR000688; HypA/HybF.
DR   PANTHER; PTHR34535; PTHR34535; 1.
DR   Pfam; PF01155; HypA; 1.
DR   PIRSF; PIRSF004761; Hydrgn_mat_HypA; 1.
DR   TIGRFAMs; TIGR00100; hypA; 1.
DR   PROSITE; PS01249; HYPA; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Nickel; Zinc.
FT   CHAIN           1..112
FT                   /note="Hydrogenase maturation factor HypA"
FT                   /id="PRO_0000129052"
FT   BINDING         2
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT   BINDING         73
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT   BINDING         76
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT   BINDING         88
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
FT   BINDING         91
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00213"
SQ   SEQUENCE   112 AA;  12219 MW;  2D1AD88B6C3F95CB CRC64;
     MHELSLATAL VETALWQAVQ AEAQQIVSLK LRLGTWAGVD AEALRFAFSL VQQDTIAASA
     QLVIESVPAQ FRCQTCGQQT PPPLLAACSH CGSDRWQLQQ GRELQLQSME VV