HYPB_HELPJ
ID HYPB_HELPJ Reviewed; 242 AA.
AC Q9ZKU8;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Hydrogenase/urease maturation factor HypB {ECO:0000250|UniProtKB:O25560};
GN Name=hypB; OrderedLocusNames=jhp_0837;
OS Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J99 / ATCC 700824;
RX PubMed=9923682; DOI=10.1038/16495;
RA Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT "Genomic sequence comparison of two unrelated isolates of the human gastric
RT pathogen Helicobacter pylori.";
RL Nature 397:176-180(1999).
CC -!- FUNCTION: Involved in the maturation of [NiFe] hydrogenases. Required
CC for nickel insertion into the metal center of the hydrogenase. Exhibits
CC a low intrinsic GTPase activity, which is essential for nickel
CC insertion. {ECO:0000250|UniProtKB:P0AAN3}.
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM
CC subfamily. {ECO:0000305}.
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DR EMBL; AE001439; AAD06415.1; -; Genomic_DNA.
DR PIR; H71883; H71883.
DR RefSeq; WP_000003585.1; NZ_CP011330.1.
DR AlphaFoldDB; Q9ZKU8; -.
DR SMR; Q9ZKU8; -.
DR STRING; 85963.jhp_0837; -.
DR EnsemblBacteria; AAD06415; AAD06415; jhp_0837.
DR KEGG; hpj:jhp_0837; -.
DR PATRIC; fig|85963.30.peg.130; -.
DR eggNOG; COG0378; Bacteria.
DR OMA; ECHLDAH; -.
DR Proteomes; UP000000804; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR GO; GO:0051604; P:protein maturation; IEA:InterPro.
DR CDD; cd05390; HypB; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR004392; Hyd_mat_HypB.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR30134; PTHR30134; 1.
DR Pfam; PF02492; cobW; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00073; hypB; 1.
PE 3: Inferred from homology;
KW GTP-binding; Hydrolase; Metal-binding; Nickel; Nucleotide-binding; Zinc.
FT CHAIN 1..242
FT /note="Hydrogenase/urease maturation factor HypB"
FT /id="PRO_0000201443"
FT REGION 48..211
FT /note="G-domain"
FT /evidence="ECO:0000250|UniProtKB:P0AAN3"
FT BINDING 106
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000250|UniProtKB:O25560"
FT BINDING 106
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:O25560"
FT BINDING 107
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000250|UniProtKB:O25560"
FT BINDING 142
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000250|UniProtKB:O25560"
FT BINDING 142
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:O25560"
SQ SEQUENCE 242 AA; 27339 MW; E73A0A1B953B40FF CRC64;
MSEQRKESLQ NNPNLSKKDI KIVEKILSKN DIKAAEMKER YLKEGLYVLN FMSSPGSGKT
TMLENLADFK DFKFCVVEGD LQTNRDADRL RKKGVSAHQI TTGEACHLEA SMIEGAFDLL
KDEGALEKSD FLIIENVGNL VCPSSYNLGA AMNIVLLSVP EGDDKVLKYP TMFMCADAVI
ISKADMIEVF NFRVSQVKED MQKLKPEAPI FLMSSKDPKS LEDFKNFLLE KKRENYQSTH
SF
