ID   HYPC_ECO57              Reviewed;          90 AA.
AC   P0AAM5; P24191;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Hydrogenase maturation factor HypC {ECO:0000250|UniProtKB:P0AAM3};
GN   Name=hypC; OrderedLocusNames=Z4037, ECs3584;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Involved in the maturation of [NiFe] hydrogenases. Involved
CC       in the biosynthesis of the Fe(CN)(2)CO cofactor. HypC delivers iron-
CC       bound CO(2) to HypD where reduction to CO probably occurs. In complex
CC       with HypD, accepts the cyanide ligand generated by HypF and HypE, and
CC       also coordinates the carbon monoxide ligand.
CC       {ECO:0000250|UniProtKB:P0AAM3}.
CC   -!- PATHWAY: Protein modification; [NiFe] hydrogenase maturation.
CC       {ECO:0000250|UniProtKB:P0AAM3}.
CC   -!- SIMILARITY: Belongs to the HupF/HypC family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG57836.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37007.1; -; Genomic_DNA.
DR   PIR; H85921; H85921.
DR   PIR; H91076; H91076.
DR   RefSeq; NP_311611.1; NC_002695.1.
DR   RefSeq; WP_000334881.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AAM5; -.
DR   BMRB; P0AAM5; -.
DR   SMR; P0AAM5; -.
DR   STRING; 155864.EDL933_3898; -.
DR   EnsemblBacteria; AAG57836; AAG57836; Z4037.
DR   EnsemblBacteria; BAB37007; BAB37007; ECs_3584.
DR   GeneID; 67413974; -.
DR   GeneID; 914694; -.
DR   KEGG; ece:Z4037; -.
DR   KEGG; ecs:ECs_3584; -.
DR   PATRIC; fig|386585.9.peg.3746; -.
DR   eggNOG; COG0298; Bacteria.
DR   HOGENOM; CLU_159381_1_1_6; -.
DR   OMA; MCLAIPC; -.
DR   UniPathway; UPA00335; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   InterPro; IPR019812; Hydgase_assmbl_chp_CS.
DR   InterPro; IPR001109; Hydrogenase_HupF/HypC.
DR   PANTHER; PTHR35177; PTHR35177; 1.
DR   Pfam; PF01455; HupF_HypC; 1.
DR   PRINTS; PR00445; HUPFHYPC.
DR   TIGRFAMs; TIGR00074; hypC_hupF; 1.
DR   PROSITE; PS01097; HUPF_HYPC; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..90
FT                   /note="Hydrogenase maturation factor HypC"
FT                   /id="PRO_0000201399"
FT   SITE            2
FT                   /note="Important for interaction with HypD and the
FT                   precursor form of hydrogenase"
FT                   /evidence="ECO:0000250|UniProtKB:P0AAM3"
SQ   SEQUENCE   90 AA;  9732 MW;  FBE252F1875C7879 CRC64;
     MCIGVPGQIR TIDGNQAKVD VCGIQRDVDL TLVGSCDENG QPRVGQWVLV HVGFAMSVIN
     EAEARDTLDA LQNMFDVEPD VGALLYGEEK