HYPC_SHIFL
ID HYPC_SHIFL Reviewed; 90 AA.
AC P0AAM6; P24191;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Hydrogenase maturation factor HypC {ECO:0000250|UniProtKB:P0AAM3};
GN Name=hypC; OrderedLocusNames=SF2745, S2937;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Involved in the maturation of [NiFe] hydrogenases. Involved
CC in the biosynthesis of the Fe(CN)(2)CO cofactor. HypC delivers iron-
CC bound CO(2) to HypD where reduction to CO probably occurs. In complex
CC with HypD, accepts the cyanide ligand generated by HypF and HypE, and
CC also coordinates the carbon monoxide ligand.
CC {ECO:0000250|UniProtKB:P0AAM3}.
CC -!- PATHWAY: Protein modification; [NiFe] hydrogenase maturation.
CC {ECO:0000250|UniProtKB:P0AAM3}.
CC -!- SIMILARITY: Belongs to the HupF/HypC family. {ECO:0000305}.
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DR EMBL; AE005674; AAN44236.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP18063.1; -; Genomic_DNA.
DR RefSeq; NP_708529.1; NC_004337.2.
DR RefSeq; WP_000334881.1; NZ_WPGW01000014.1.
DR AlphaFoldDB; P0AAM6; -.
DR BMRB; P0AAM6; -.
DR SMR; P0AAM6; -.
DR STRING; 198214.SF2745; -.
DR EnsemblBacteria; AAN44236; AAN44236; SF2745.
DR EnsemblBacteria; AAP18063; AAP18063; S2937.
DR GeneID; 1023542; -.
DR GeneID; 67413974; -.
DR KEGG; sfl:SF2745; -.
DR KEGG; sfx:S2937; -.
DR PATRIC; fig|198214.7.peg.3268; -.
DR HOGENOM; CLU_159381_1_1_6; -.
DR OMA; MCLAIPC; -.
DR OrthoDB; 2031925at2; -.
DR UniPathway; UPA00335; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR InterPro; IPR019812; Hydgase_assmbl_chp_CS.
DR InterPro; IPR001109; Hydrogenase_HupF/HypC.
DR PANTHER; PTHR35177; PTHR35177; 1.
DR Pfam; PF01455; HupF_HypC; 1.
DR PRINTS; PR00445; HUPFHYPC.
DR TIGRFAMs; TIGR00074; hypC_hupF; 1.
DR PROSITE; PS01097; HUPF_HYPC; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..90
FT /note="Hydrogenase maturation factor HypC"
FT /id="PRO_0000201401"
FT SITE 2
FT /note="Important for interaction with HypD and the
FT precursor form of hydrogenase"
FT /evidence="ECO:0000250|UniProtKB:P0AAM3"
SQ SEQUENCE 90 AA; 9732 MW; FBE252F1875C7879 CRC64;
MCIGVPGQIR TIDGNQAKVD VCGIQRDVDL TLVGSCDENG QPRVGQWVLV HVGFAMSVIN
EAEARDTLDA LQNMFDVEPD VGALLYGEEK
