ID   HYPD_AZOVI              Reviewed;         379 AA.
AC   P31882;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Hydrogenase maturation factor HypD {ECO:0000250|UniProtKB:P24192};
GN   Name=hypD;
OS   Azotobacter vinelandii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Azotobacter.
OX   NCBI_TaxID=354;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 13705 / OP1 / DSM 366 / NCIMB 11614 / LMG 3878 / UW;
RX   PubMed=1610901; DOI=10.1016/0167-4781(92)90077-d;
RA   Chen J.C., Mortenson L.E.;
RT   "Identification of six open reading frames from a region of the Azotobacter
RT   vinelandii genome likely involved in dihydrogen metabolism.";
RL   Biochim. Biophys. Acta 1131:199-202(1992).
CC   -!- FUNCTION: Involved in the maturation of [NiFe] hydrogenases. Involved
CC       in the biosynthesis of the Fe(CN)(2)CO cofactor.
CC       {ECO:0000250|UniProtKB:P24192}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000250|UniProtKB:P24192};
CC   -!- PATHWAY: Protein modification; [NiFe] hydrogenase maturation.
CC       {ECO:0000250|UniProtKB:P24192}.
CC   -!- SIMILARITY: Belongs to the HypD family. {ECO:0000305}.
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DR   EMBL; X63650; CAA45187.1; -; Genomic_DNA.
DR   EMBL; L23970; AAA19512.1; -; Unassigned_DNA.
DR   PIR; S23443; S23443.
DR   RefSeq; WP_012703486.1; NZ_FPKM01000029.1.
DR   AlphaFoldDB; P31882; -.
DR   SMR; P31882; -.
DR   OMA; PWALMEV; -.
DR   UniPathway; UPA00335; -.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.11740; -; 2.
DR   Gene3D; 6.10.20.100; -; 1.
DR   InterPro; IPR002780; Hyd_form_HypD.
DR   InterPro; IPR042243; HypD_1.
DR   InterPro; IPR042244; HypD_2_sf.
DR   PANTHER; PTHR30149; PTHR30149; 1.
DR   Pfam; PF01924; HypD; 1.
DR   PIRSF; PIRSF005622; Hydrgn_mat_hypD; 1.
DR   TIGRFAMs; TIGR00075; hypD; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding.
FT   CHAIN           1..379
FT                   /note="Hydrogenase maturation factor HypD"
FT                   /id="PRO_0000201448"
FT   BINDING         36
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250|UniProtKB:P24192"
FT   BINDING         64
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250|UniProtKB:P24192"
FT   BINDING         67
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250|UniProtKB:P24192"
SQ   SEQUENCE   379 AA;  41228 MW;  6917DA64C7C4E32D CRC64;
     MKYVDEFRDG ATARQLAARI AAEADPKRQY RLMEFCGGHT HAIFRYGIPD LLPANVRLIH
     GPGCPVCVMP IGRLDMAIEL ARRPGVILCT YGDMLRVPAS GRVSLLKARA EGAAVRMLYS
     PIEALKLAQD NPDRDVVFFA IGFETTTPPT ALVIEQAQRL GLKNFSVFCN HVLTPAAMHA
     ILATPEARAG TLQLDGFIGP AHVSTVIGSD AYAPFPRQYG TPLVIAGFEP LDLLQALLML
     VRQLNEGRAE VENQFTRAVT AGGNLKAKAL TGRIFELRES FEWRGLGALP NSALRIREAF
     AEFDAERRFA LEARSGLENK ACECPAILRG AKSPRDCKLF GNPCSPDNPL GSCMVSSEGA
     CAAWYAYGRQ RQAVVAVAR