ID   HYPD_RHOCA              Reviewed;         377 AA.
AC   P26411;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 2.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Hydrogenase maturation factor HypD {ECO:0000250|UniProtKB:P24192};
GN   Name=hypD;
OS   Rhodobacter capsulatus (Rhodopseudomonas capsulata).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Rhodobacter.
OX   NCBI_TaxID=1061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 33303 / B10;
RX   PubMed=8497190; DOI=10.1111/j.1365-2958.1993.tb01199.x;
RA   Colbeau A., Richaud P., Toussaint B., Caballero F.J., Elster C.,
RA   Delphin C., Smith R.L., Chabert J., Vignais P.M.;
RT   "Organization of the genes necessary for hydrogenase expression in
RT   Rhodobacter capsulatus. Sequence analysis and identification of two hyp
RT   regulatory mutants.";
RL   Mol. Microbiol. 8:15-29(1993).
CC   -!- FUNCTION: Involved in the maturation of [NiFe] hydrogenases. Involved
CC       in the biosynthesis of the Fe(CN)(2)CO cofactor.
CC       {ECO:0000250|UniProtKB:P24192}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000250|UniProtKB:P24192};
CC   -!- PATHWAY: Protein modification; [NiFe] hydrogenase maturation.
CC       {ECO:0000250|UniProtKB:P24192}.
CC   -!- SIMILARITY: Belongs to the HypD family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA43328.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X61007; CAA43328.1; ALT_INIT; Genomic_DNA.
DR   PIR; S59984; S59984.
DR   RefSeq; WP_013066524.1; NC_014034.1.
DR   AlphaFoldDB; P26411; -.
DR   SMR; P26411; -.
DR   GeneID; 31489722; -.
DR   OMA; HVCGSHE; -.
DR   UniPathway; UPA00335; -.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.11750; -; 2.
DR   Gene3D; 6.10.20.100; -; 1.
DR   InterPro; IPR002780; Hyd_form_HypD.
DR   InterPro; IPR042243; HypD_1.
DR   InterPro; IPR042244; HypD_2_sf.
DR   PANTHER; PTHR30149; PTHR30149; 1.
DR   Pfam; PF01924; HypD; 1.
DR   PIRSF; PIRSF005622; Hydrgn_mat_hypD; 1.
DR   TIGRFAMs; TIGR00075; hypD; 1.
PE   1: Evidence at protein level;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding.
FT   CHAIN           1..377
FT                   /note="Hydrogenase maturation factor HypD"
FT                   /id="PRO_0000201453"
FT   BINDING         41
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250|UniProtKB:P24192"
FT   BINDING         69
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250|UniProtKB:P24192"
FT   BINDING         72
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250|UniProtKB:P24192"
FT   MUTAGEN         346..362
FT                   /note="Missing: In RCC12 mutant; results in loss of
FT                   hydrogenase activity."
SQ   SEQUENCE   377 AA;  40667 MW;  7BB22FC248B49A3F CRC64;
     MKFASEFRDP ALAKGLLAEI ARLADQIGAT AEKPVHIMEI CGGHTHSIFR YGLDKLIHPG
     IEFIHGPGCP VCVLPRARVD ECIEIAGRPE VIFCTFGDAM RVPGSKLSLM QAKAAGADIR
     MVYSPLDALE LARRNPGREV VFFGLGFETT TPSTALAIQQ AAREGLANFS VFCNHITVPE
     PIRALLDDPY MRLDGFIGPG HVSMVIGIHP YDFIAEDYGK PLVVAGFEPT DLLQSVLMVL
     RQISQGRAAI ENQYARVVPE HGNRVSLAAI ADVYERRPSF EWRGLGEIDA SGLRIRAAYR
     AHDAEEKFGV GYAGQRAAVE EAEGCACGAV MTGRMKPVAC AQFGKGCTPE MPLGALMVSS
     EGACAAYWQY GGARAAE