HYPM_HUMAN
ID HYPM_HUMAN Reviewed; 117 AA.
AC O75409; A1A4D3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Huntingtin-interacting protein M {ECO:0000305};
DE AltName: Full=Histone H2A.P {ECO:0000312|HGNC:HGNC:18417};
DE AltName: Full=Huntingtin yeast partner M;
GN Name=H2AP {ECO:0000312|HGNC:HGNC:18417};
GN Synonyms=CXorf27 {ECO:0000312|HGNC:HGNC:18417},
GN HYPM {ECO:0000312|HGNC:HGNC:18417};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND POSSIBLE INTERACTION WITH HD.
RC TISSUE=Testis;
RX PubMed=9700202; DOI=10.1093/hmg/7.9.1463;
RA Faber P.W., Barnes G.T., Srinidhi J., Chen J., Gusella J.F.,
RA MacDonald M.E.;
RT "Huntingtin interacts with a family of WW domain proteins.";
RL Hum. Mol. Genet. 7:1463-1474(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: May interact with the N-terminus of HD.
CC -!- INTERACTION:
CC O75409; P02649: APOE; NbExp=3; IntAct=EBI-6447217, EBI-1222467;
CC O75409; P54252: ATXN3; NbExp=3; IntAct=EBI-6447217, EBI-946046;
CC O75409; P06307: CCK; NbExp=3; IntAct=EBI-6447217, EBI-6624398;
CC O75409; P48643: CCT5; NbExp=3; IntAct=EBI-6447217, EBI-355710;
CC O75409; Q9H3R5: CENPH; NbExp=3; IntAct=EBI-6447217, EBI-1003700;
CC O75409; Q9C0F1: CEP44; NbExp=6; IntAct=EBI-6447217, EBI-744115;
CC O75409; Q53GS7: GLE1; NbExp=3; IntAct=EBI-6447217, EBI-1955541;
CC O75409; P28799: GRN; NbExp=3; IntAct=EBI-6447217, EBI-747754;
CC O75409; P42858: HTT; NbExp=16; IntAct=EBI-6447217, EBI-466029;
CC O75409; P13473-2: LAMP2; NbExp=3; IntAct=EBI-6447217, EBI-21591415;
CC O75409; O15481: MAGEB4; NbExp=3; IntAct=EBI-6447217, EBI-751857;
CC O75409; P15173: MYOG; NbExp=6; IntAct=EBI-6447217, EBI-3906629;
CC O75409; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-6447217, EBI-741158;
CC O75409; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-6447217, EBI-2623095;
CC O75409; Q15475: SIX1; NbExp=3; IntAct=EBI-6447217, EBI-743675;
CC O75409; O76024: WFS1; NbExp=3; IntAct=EBI-6447217, EBI-720609;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC26851.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF049615; AAC26851.1; ALT_INIT; mRNA.
DR EMBL; CH471141; EAW59451.1; -; Genomic_DNA.
DR EMBL; BC104428; AAI04429.1; -; mRNA.
DR EMBL; BC104429; AAI04430.1; -; mRNA.
DR EMBL; BC113024; AAI13025.1; -; mRNA.
DR EMBL; BC113025; AAI13026.1; -; mRNA.
DR CCDS; CCDS43929.1; -.
DR RefSeq; NP_036406.1; NM_012274.1.
DR AlphaFoldDB; O75409; -.
DR SMR; O75409; -.
DR BioGRID; 117303; 88.
DR IntAct; O75409; 18.
DR STRING; 9606.ENSP00000339511; -.
DR iPTMnet; O75409; -.
DR PhosphoSitePlus; O75409; -.
DR BioMuta; HYPM; -.
DR MassIVE; O75409; -.
DR PaxDb; O75409; -.
DR PeptideAtlas; O75409; -.
DR PRIDE; O75409; -.
DR ProteomicsDB; 49976; -.
DR Antibodypedia; 567; 41 antibodies from 11 providers.
DR DNASU; 25763; -.
DR Ensembl; ENST00000341016.5; ENSP00000339511.3; ENSG00000187516.7.
DR GeneID; 25763; -.
DR KEGG; hsa:25763; -.
DR MANE-Select; ENST00000341016.5; ENSP00000339511.3; NM_012274.2; NP_036406.1.
DR UCSC; uc004ddt.4; human.
DR CTD; 25763; -.
DR DisGeNET; 25763; -.
DR GeneCards; H2AP; -.
DR HGNC; HGNC:18417; H2AP.
DR HPA; ENSG00000187516; Tissue enriched (testis).
DR neXtProt; NX_O75409; -.
DR OpenTargets; ENSG00000187516; -.
DR VEuPathDB; HostDB:ENSG00000187516; -.
DR eggNOG; ENOG502RU2P; Eukaryota.
DR GeneTree; ENSGT00390000015623; -.
DR HOGENOM; CLU_062828_5_0_1; -.
DR InParanoid; O75409; -.
DR OMA; NGRMRNT; -.
DR OrthoDB; 1579464at2759; -.
DR PhylomeDB; O75409; -.
DR TreeFam; TF338397; -.
DR PathwayCommons; O75409; -.
DR SignaLink; O75409; -.
DR BioGRID-ORCS; 25763; 12 hits in 696 CRISPR screens.
DR GenomeRNAi; 25763; -.
DR Pharos; O75409; Tdark.
DR PRO; PR:O75409; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; O75409; protein.
DR Bgee; ENSG00000187516; Expressed in sperm and 46 other tissues.
DR Genevisible; O75409; HS.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR PANTHER; PTHR23430; PTHR23430; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..117
FT /note="Huntingtin-interacting protein M"
FT /id="PRO_0000254087"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 68
FT /note="V -> I (in dbSNP:rs6651635)"
FT /id="VAR_028810"
SQ SEQUENCE 117 AA; 13442 MW; 0F73DE715C55BBF8 CRC64;
MSEKKNCKNS STNNNQTQDP SRNELQVPRS FVDRVVQDER DVQSQSSSTI NTLLTLLDCL
ADYIMERVGL EASNNGSMRN TSQDREREVD NNREPHSAES DVTRFLFDEM PKSRKND
