HYPM_MOUSE
ID HYPM_MOUSE Reviewed; 117 AA.
AC Q9CR04;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Huntingtin-interacting protein M {ECO:0000305};
DE AltName: Full=Histone H2A.P {ECO:0000312|MGI:MGI:1914584};
DE AltName: Full=Huntingtin yeast partner M;
GN Name=H2ap {ECO:0000312|MGI:MGI:1914584};
GN Synonyms=Hypm {ECO:0000312|MGI:MGI:1914584};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: May interact with the N-terminus of HD. {ECO:0000250}.
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DR EMBL; AK006319; BAB24525.1; -; mRNA.
DR EMBL; AK006788; BAB24739.1; -; mRNA.
DR EMBL; BC049569; AAH49569.1; -; mRNA.
DR EMBL; BC059721; AAH59721.1; -; mRNA.
DR CCDS; CCDS30012.1; -.
DR RefSeq; NP_080372.1; NM_026096.1.
DR AlphaFoldDB; Q9CR04; -.
DR SMR; Q9CR04; -.
DR STRING; 10090.ENSMUSP00000043734; -.
DR PhosphoSitePlus; Q9CR04; -.
DR PaxDb; Q9CR04; -.
DR PRIDE; Q9CR04; -.
DR Antibodypedia; 567; 41 antibodies from 11 providers.
DR DNASU; 67334; -.
DR Ensembl; ENSMUST00000044987; ENSMUSP00000043734; ENSMUSG00000040456.
DR GeneID; 67334; -.
DR KEGG; mmu:67334; -.
DR UCSC; uc009spz.1; mouse.
DR CTD; 25763; -.
DR MGI; MGI:1914584; H2ap.
DR VEuPathDB; HostDB:ENSMUSG00000040456; -.
DR eggNOG; ENOG502RU2P; Eukaryota.
DR GeneTree; ENSGT00390000015623; -.
DR HOGENOM; CLU_062828_5_0_1; -.
DR InParanoid; Q9CR04; -.
DR OMA; NGRMRNT; -.
DR OrthoDB; 1579464at2759; -.
DR PhylomeDB; Q9CR04; -.
DR TreeFam; TF338397; -.
DR BioGRID-ORCS; 67334; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q9CR04; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9CR04; protein.
DR Bgee; ENSMUSG00000040456; Expressed in seminiferous tubule of testis and 5 other tissues.
DR Genevisible; Q9CR04; MM.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR PANTHER; PTHR23430; PTHR23430; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..117
FT /note="Huntingtin-interacting protein M"
FT /id="PRO_0000254088"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 117 AA; 13492 MW; 38BCE6F068FB72CE CRC64;
MSEKKSQEKP CSDNNQIEDP SSRPEVQVPV NYVYRILQEE QYTPCIGSTT SDFLLAMLDY
LTDYILEVVG SEANINNQQN ISQDRERQRD NDREPSRGFK NAPFSLFDEM PGPRRNG
