ID   HYTA_APIME              Reviewed;         129 AA.
AC   Q10416;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Hymenoptaecin;
DE   Flags: Precursor;
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Apis.
OX   NCBI_TaxID=7460;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7961803; DOI=10.1016/s0021-9258(19)61943-5;
RA   Casteels-Josson K., Zhang W., Capaci T., Casteels P., Tempst P.;
RT   "Acute transcriptional response of the honeybee peptide-antibiotics gene
RT   repertoire and required post-translational conversion of the precursor
RT   structures.";
RL   J. Biol. Chem. 269:28569-28575(1994).
CC   -!- FUNCTION: This peptide has antibacterial activity.
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DR   EMBL; U15956; AAA67444.1; -; mRNA.
DR   PIR; A55392; A55392.
DR   RefSeq; NP_001011615.1; NM_001011615.1.
DR   AlphaFoldDB; Q10416; -.
DR   STRING; 7460.GB51223-PA; -.
DR   PaxDb; Q10416; -.
DR   EnsemblMetazoa; NM_001011615; NP_001011615; LOC406142.
DR   GeneID; 406142; -.
DR   KEGG; ame:406142; -.
DR   HOGENOM; CLU_1950602_0_0_1; -.
DR   InParanoid; Q10416; -.
DR   OMA; IRSHTEF; -.
DR   OrthoDB; 408767at2759; -.
DR   Proteomes; UP000005203; Unplaced.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Immunity;
KW   Innate immunity; Reference proteome; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..36
FT                   /id="PRO_0000021474"
FT   CHAIN           37..129
FT                   /note="Hymenoptaecin"
FT                   /id="PRO_0000021475"
FT   VARIANT         2
FT                   /note="K -> N"
FT   VARIANT         5
FT                   /note="V -> L"
FT   VARIANT         85
FT                   /note="P -> S"
SQ   SEQUENCE   129 AA;  14492 MW;  0A5BB1AC976EF6D9 CRC64;
     MKFIVLVLFC AVAYVSAQAE LEPEDTMDYI PTRFRRQERG SIVIQGTKEG KSRPSLDIDY
     KQRVYDKNGM TGDAYGGLNI RPGQPSRQHA GFEFGKEYKN GFIKGQSEVQ RGPGGRLSPY
     FGINGGFRF