ID   HYTL_TITSE              Reviewed;          73 AA.
AC   P86824;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 2.
DT   03-AUG-2022, entry version 9.
DE   RecName: Full=Hypotensin-like peptide {ECO:0000303|PubMed:18718845};
DE   Flags: Precursor;
OS   Tityus serrulatus (Brazilian scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=6887;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   DOI=10.4236/ojgen.2012.24027;
RA   Alvarenga E.R., Mendes T.M., Magalhaes B.F., Siqueira F.F., Dantas A.E.,
RA   Barroca T.M., Horta C.C., Kalapothakis E.;
RT   "Transcriptome analysis of the Tityus serrulatus scorpion venom gland.";
RL   O. J. Gen. 2:210-220(2012).
RN   [2]
RP   PROTEIN SEQUENCE OF 37-50, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=18718845; DOI=10.1016/j.toxicon.2008.07.010;
RA   Rates B., Ferraz K.K., Borges M.H., Richardson M., De Lima M.E.,
RA   Pimenta A.M.;
RT   "Tityus serrulatus venom peptidomics: assessing venom peptide diversity.";
RL   Toxicon 52:611-618(2008).
CC   -!- FUNCTION: May potentiate the hypotensive effect of bradykinin.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18718845}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:18718845, ECO:0000305|PubMed:18718845}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hypotensive agent; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         26..73
FT                   /note="Hypotensin-like peptide"
FT                   /evidence="ECO:0000269|PubMed:18718845"
FT                   /id="PRO_0000401166"
SQ   SEQUENCE   73 AA;  8146 MW;  AA9F91DE7BFC7A1F CRC64;
     MKMMIAIVFV SILLLMFSLS STAMGMETEQ QNMEERADVD FTGIADSIIK KIKETNAKPP
     ARFDPATFGE NED