I11RB_MOUSE
ID I11RB_MOUSE Reviewed; 432 AA.
AC P70225; A2RTL4; B1AXR8; O09074; Q78DW8;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 4.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Interleukin-11 receptor subunit alpha-2;
DE Short=IL-11 receptor subunit alpha-2;
DE Short=IL-11R subunit alpha-2;
DE Short=IL-11R-alpha-2;
DE Short=IL-11RA2;
DE AltName: Full=Interleukin-11 receptor subunit beta;
DE Short=IL-11 receptor subunit beta;
DE Short=IL-11R subunit beta;
DE Short=IL-11R-beta;
DE Short=IL-11RB;
DE Flags: Precursor;
GN Name=Il11ra2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=CD-1; TISSUE=Testis;
RX PubMed=8973540; DOI=10.1042/bj3200359;
RA Bilinski P., Hall M.A., Neuhaus H., Gissel C., Heath J.K., Gossler A.;
RT "Two differentially expressed interleukin-11 receptor genes in the mouse
RT genome.";
RL Biochem. J. 320:359-363(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129/Sv; TISSUE=Testis;
RX PubMed=8662802; DOI=10.1074/jbc.271.23.13754;
RA Robb L., Hilton D.J., Willson T.A., Begley C.G.;
RT "Structural analysis of the gene encoding the murine interleukin-11
RT receptor alpha-chain and a related locus.";
RL J. Biol. Chem. 271:13754-13761(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=CD-1; TISSUE=Testis;
RX PubMed=9073505; DOI=10.1006/geno.1996.4579;
RA Robb L., Hilton D.J., Brook-Carter P.T., Begley C.G.;
RT "Identification of a second murine interleukin-11 receptor alpha-chain gene
RT (IL11Ra2) with a restricted pattern of expression.";
RL Genomics 40:387-394(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for interleukin-11. The receptor systems for IL6,
CC LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal
CC transmission. The IL11/IL11RA/IL6ST complex may be involved in the
CC control of proliferation and/or differentiation of skeletogenic
CC progenitor or other mesenchymal cells.
CC -!- SUBUNIT: On ligand binding, forms a multimer complex with IL6ST/gp130.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- TISSUE SPECIFICITY: Expression restricted to testis, lymph node and
CC thymus. Highest level in testis. {ECO:0000269|PubMed:9073505}.
CC -!- MISCELLANEOUS: Il11ra2 appears to arise through gene duplication of
CC ancestral origin and has been lost in some inbred mouse strains.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3
CC subfamily. {ECO:0000305}.
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DR EMBL; X94157; CAA63872.1; -; Genomic_DNA.
DR EMBL; X94158; CAA63872.1; JOINED; Genomic_DNA.
DR EMBL; X94159; CAA63872.1; JOINED; Genomic_DNA.
DR EMBL; X94160; CAA63872.1; JOINED; Genomic_DNA.
DR EMBL; X94161; CAA63872.1; JOINED; Genomic_DNA.
DR EMBL; X98519; CAA67144.1; -; mRNA.
DR EMBL; U69491; AAC53114.1; -; mRNA.
DR EMBL; AL824709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC132549; AAI32550.1; -; mRNA.
DR EMBL; BC138592; AAI38593.1; -; mRNA.
DR EMBL; BC145341; AAI45342.1; -; mRNA.
DR CCDS; CCDS38735.1; -.
DR RefSeq; NP_001092818.1; NM_001099348.1.
DR RefSeq; NP_001094066.1; NM_001100596.1.
DR RefSeq; NP_034680.3; NM_010550.3.
DR AlphaFoldDB; P70225; -.
DR SMR; P70225; -.
DR STRING; 10090.ENSMUSP00000095725; -.
DR GlyGen; P70225; 2 sites.
DR PaxDb; P70225; -.
DR PRIDE; P70225; -.
DR DNASU; 16158; -.
DR Ensembl; ENSMUST00000098121; ENSMUSP00000095725; ENSMUSG00000073876.
DR Ensembl; ENSMUST00000108006; ENSMUSP00000103641; ENSMUSG00000078735.
DR Ensembl; ENSMUST00000238770; ENSMUSP00000158819; ENSMUSG00000078735.
DR GeneID; 100042555; -.
DR GeneID; 16158; -.
DR KEGG; mmu:100042555; -.
DR KEGG; mmu:16158; -.
DR UCSC; uc008slo.1; mouse.
DR CTD; 16158; -.
DR MGI; MGI:109123; Il11ra2.
DR VEuPathDB; HostDB:ENSMUSG00000073876; -.
DR VEuPathDB; HostDB:ENSMUSG00000078735; -.
DR VEuPathDB; HostDB:ENSMUSG00000095456; -.
DR VEuPathDB; HostDB:ENSMUSG00000095623; -.
DR eggNOG; ENOG502R7G6; Eukaryota.
DR GeneTree; ENSGT00940000160904; -.
DR HOGENOM; CLU_047259_0_1_1; -.
DR InParanoid; P70225; -.
DR OMA; YISLCIH; -.
DR OrthoDB; 741136at2759; -.
DR PhylomeDB; P70225; -.
DR TreeFam; TF331210; -.
DR BioGRID-ORCS; 100038993; 0 hits in 11 CRISPR screens.
DR BioGRID-ORCS; 100042555; 0 hits in 13 CRISPR screens.
DR BioGRID-ORCS; 16158; 1 hit in 18 CRISPR screens.
DR ChiTaRS; Il11ra2; mouse.
DR PRO; PR:P70225; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; P70225; protein.
DR Bgee; ENSMUSG00000073876; Expressed in spermatocyte and 43 other tissues.
DR Genevisible; P70225; MM.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0019970; F:interleukin-11 binding; IBA:GO_Central.
DR GO; GO:0004921; F:interleukin-11 receptor activity; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF49265; SSF49265; 2.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS01354; HEMATOPO_REC_L_F3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..432
FT /note="Interleukin-11 receptor subunit alpha-2"
FT /id="PRO_0000010915"
FT TOPO_DOM 24..372
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 394..432
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 27..110
FT /note="Ig-like C2-type"
FT DOMAIN 112..219
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 220..317
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 151..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 304..308
FT /note="WSXWS motif"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 48..94
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 120..130
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 170..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 200
FT /note="P -> S (in Ref. 1; CAA67144, 3; AAC53114 and 5;
FT AAI32550)"
FT /evidence="ECO:0000305"
FT CONFLICT 384
FT /note="V -> L (in Ref. 1; CAA63872)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 432 AA; 46731 MW; 70C8AD1C7994EB12 CRC64;
MSSSCSGLTR VLVAVATALV SSSSPCPQAW GPPGVQYGQP GRPVMLCCPG VSAGTPVSWF
RDGDSRLLQG PDSGLGHRLV LAQVDSPDEG TYVCQTLDGV SGGMVTLKLG FPPARPEVSC
QAVDYENFSC TWSPGQVSGL PTRYLTSYRK KTLPGAESQR ESPSTGPWPC PQDPLEASRC
VVHGAEFWSE YRINVTEVNP LGASTCLLDV RLQSILRPDP PQGLRVESVP GYPRRLHASW
TYPASWRRQP HFLLKFRLQY RPAQHPAWST VEPIGLEEVI TDTVAGLPHA VRVSARDFLD
AGTWSAWSPE AWGTPSTGLL QDEIPDWSQG HGQQLEAVVA QEDSLAPARP SLQPDPRPLD
HRDPLEQVAV LASLGIFSCL GLAVGALALG LWLRLRRSGK EGPQKPGLLA PMIPVEKLPG
IPNLQRTPEN FS
