I17EL_HUMAN
ID I17EL_HUMAN Reviewed; 336 AA.
AC Q6ZVW7; A6NCN4; A6PVC1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Putative interleukin-17 receptor E-like;
DE Short=IL-17 receptor E-like;
DE Short=IL-17RE-like;
GN Name=IL17REL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
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DR EMBL; AK123987; BAC85743.1; -; mRNA.
DR EMBL; AL022327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS33679.1; -.
DR RefSeq; NP_001001694.2; NM_001001694.2.
DR AlphaFoldDB; Q6ZVW7; -.
DR SMR; Q6ZVW7; -.
DR BioGRID; 134822; 1.
DR STRING; 9606.ENSP00000374633; -.
DR iPTMnet; Q6ZVW7; -.
DR PhosphoSitePlus; Q6ZVW7; -.
DR BioMuta; IL17REL; -.
DR DMDM; 172046175; -.
DR jPOST; Q6ZVW7; -.
DR MassIVE; Q6ZVW7; -.
DR PaxDb; Q6ZVW7; -.
DR PeptideAtlas; Q6ZVW7; -.
DR PRIDE; Q6ZVW7; -.
DR Antibodypedia; 52494; 13 antibodies from 8 providers.
DR DNASU; 400935; -.
DR Ensembl; ENST00000341280.5; ENSP00000342520.5; ENSG00000188263.10.
DR Ensembl; ENST00000389983.6; ENSP00000374633.2; ENSG00000188263.10.
DR GeneID; 400935; -.
DR KEGG; hsa:400935; -.
DR UCSC; uc003bje.2; human.
DR CTD; 400935; -.
DR DisGeNET; 400935; -.
DR GeneCards; IL17REL; -.
DR HGNC; HGNC:33808; IL17REL.
DR HPA; ENSG00000188263; Tissue enhanced (lymphoid tissue, stomach).
DR MIM; 613414; gene.
DR neXtProt; NX_Q6ZVW7; -.
DR OpenTargets; ENSG00000188263; -.
DR PharmGKB; PA162391970; -.
DR VEuPathDB; HostDB:ENSG00000188263; -.
DR eggNOG; ENOG502QTUV; Eukaryota.
DR GeneTree; ENSGT00940000162605; -.
DR HOGENOM; CLU_039632_0_0_1; -.
DR InParanoid; Q6ZVW7; -.
DR OMA; TVYYHPG; -.
DR OrthoDB; 441889at2759; -.
DR PhylomeDB; Q6ZVW7; -.
DR TreeFam; TF335690; -.
DR PathwayCommons; Q6ZVW7; -.
DR BioGRID-ORCS; 400935; 8 hits in 1079 CRISPR screens.
DR ChiTaRS; IL17REL; human.
DR GenomeRNAi; 400935; -.
DR Pharos; Q6ZVW7; Tdark.
DR PRO; PR:Q6ZVW7; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q6ZVW7; protein.
DR Bgee; ENSG00000188263; Expressed in mucosa of stomach and 27 other tissues.
DR GO; GO:0030368; F:interleukin-17 receptor activity; IBA:GO_Central.
DR InterPro; IPR039465; IL-17_rcpt-like.
DR InterPro; IPR027841; IL-17_rcpt_C/E_N.
DR PANTHER; PTHR15583; PTHR15583; 1.
DR Pfam; PF15037; IL17_R_N; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..336
FT /note="Putative interleukin-17 receptor E-like"
FT /id="PRO_0000325958"
FT VARIANT 70
FT /note="G -> R (in dbSNP:rs9617090)"
FT /id="VAR_061187"
FT VARIANT 333
FT /note="L -> P (in dbSNP:rs5771069)"
FT /id="VAR_039957"
FT CONFLICT 70..72
FT /note="GGQ -> RGR (in Ref. 1; BAC85743)"
FT /evidence="ECO:0000305"
FT CONFLICT 165
FT /note="S -> P (in Ref. 1; BAC85743)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 336 AA; 37514 MW; 971639DC7A96B7E2 CRC64;
MSRSVLEALT SSTAMQCVPS DGCAMLLRVR ASITLHERLR GLEACAMSLD TQETQCQSVW
VARASHRQQG GQQLQVHFGC FAVSVAQHLY VTLRTIPHFC GVQLDQRHLV EAGKLSYWVD
RRRKAILVQV PRASGSPDYY LRLCLKRFTC EDAGAPVRVT ANSVSQAVFL PYSQELPCLC
LEGWSATPDA VRIQICPFEN DTEALEVLWD TVYYHPESQT LSWEPACPVS GHVSLCWRPG
PGAGCRKLQQ SSQLVHRRVQ YPLVDTQPQL CLKFSTSWGS WVRCPFEQRR FPTPPTSRCT
CVTGGSHSSL PANAHSRPAR SLQPQVTWQP PLLLPS
