I17RB_HUMAN
ID I17RB_HUMAN Reviewed; 502 AA.
AC Q9NRM6; Q9BPZ0; Q9NRL4; Q9NRM5;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Interleukin-17 receptor B;
DE Short=IL-17 receptor B;
DE Short=IL-17RB;
DE AltName: Full=Cytokine receptor-like 4;
DE AltName: Full=IL-17 receptor homolog 1;
DE Short=IL-17Rh1;
DE Short=IL17Rh1;
DE AltName: Full=Interleukin-17B receptor;
DE Short=IL-17B receptor;
DE Flags: Precursor;
GN Name=IL17RB; Synonyms=CRL4, EVI27, IL17BR; ORFNames=UNQ2501/PRO19612;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=10815801; DOI=10.1038/sj.onc.1203577;
RA Tian E., Sawyer J.R., Largaespada D.A., Jenkins N.A., Copeland N.G.,
RA Shaughnessy J.D. Jr.;
RT "Evi27 encodes a novel membrane protein with homology to the IL17
RT receptor.";
RL Oncogene 19:2098-2109(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND PROTEIN SEQUENCE OF N-TERMINUS.
RC TISSUE=Lung;
RX PubMed=10749887; DOI=10.1074/jbc.m910228199;
RA Shi Y., Ullrich S.J., Zhang J., Connolly K., Grzegorzewski K.J.,
RA Barber M.C., Wang W., Wathen K., Hodge V., Fisher C.L., Olsen H.,
RA Ruben S.M., Knyazev I., Cho Y.H., Kao V., Wilkinson K.A., Carrell J.A.,
RA Ebner R.;
RT "A novel cytokine receptor-ligand pair. Identification, molecular
RT characterization, and in vivo immunomodulatory activity.";
RL J. Biol. Chem. 275:19167-19176(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Zhang W., Cao X.;
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LEU-278; THR-451; SER-458
RP AND ARG-499.
RG SeattleSNPs variation discovery resource;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 18-32.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
RN [8]
RP FUNCTION.
RX PubMed=11058597; DOI=10.1074/jbc.m008289200;
RA Lee J., Ho W.-H., Maruoka M., Corpuz R.T., Baldwin D.T., Foster J.S.,
RA Goddard A.D., Yansura D.G., Vandlen R.L., Wood W.I., Gurney A.L.;
RT "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-
RT 17Rh1.";
RL J. Biol. Chem. 276:1660-1664(2001).
RN [9]
RP SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
RX PubMed=14759258; DOI=10.1186/gb-2004-5-2-r8;
RA Hillman R.T., Green R.E., Brenner S.E.;
RT "An unappreciated role for RNA surveillance.";
RL Genome Biol. 5:R8.1-R8.16(2004).
RN [10]
RP INTERACTION WITH DAZAP2.
RX PubMed=22070932; DOI=10.1016/j.imbio.2011.10.004;
RA Popova A., Kzhyshkowska J., Nurgazieva D., Goerdt S., Gratchev A.;
RT "Smurf2 regulates IL17RB by proteasomal degradation of its novel binding
RT partner DAZAP2.";
RL Immunobiology 217:321-328(2012).
RN [11]
RP INTERACTION WITH TRAF3IP2.
RX PubMed=24120361; DOI=10.1016/j.immuni.2013.09.002;
RA Boisson B., Wang C., Pedergnana V., Wu L., Cypowyj S., Rybojad M.,
RA Belkadi A., Picard C., Abel L., Fieschi C., Puel A., Li X., Casanova J.L.;
RT "An ACT1 mutation selectively abolishes interleukin-17 responses in humans
RT with chronic mucocutaneous candidiasis.";
RL Immunity 39:676-686(2013).
CC -!- FUNCTION: Receptor for the pro-inflammatory cytokines IL17B and IL17E.
CC May play a role in controlling the growth and/or differentiation of
CC hematopoietic cells. {ECO:0000269|PubMed:11058597}.
CC -!- SUBUNIT: Interacts with DAZAP2 (PubMed:22070932). Interacts with
CC TRAF3IP2 (PubMed:24120361). {ECO:0000269|PubMed:22070932,
CC ECO:0000269|PubMed:24120361}.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I
CC membrane protein.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NRM6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NRM6-2; Sequence=VSP_001740, VSP_001741;
CC -!- TISSUE SPECIFICITY: Expressed in several endocrine tissues, mostly in
CC fetal and adult liver, kidney, pancreas, testis, colon, brain and small
CC intestine; not detected in peripheral blood leukocytes, lymphoid
CC organs, and most cell lines.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=SeattleSNPs;
CC URL="http://pga.gs.washington.edu/data/il17rb/";
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DR EMBL; AF208110; AAF86051.1; -; mRNA.
DR EMBL; AF208111; AAF86052.1; -; mRNA.
DR EMBL; AF212365; AAF78776.1; -; mRNA.
DR EMBL; AF250309; AAK37428.1; -; mRNA.
DR EMBL; AY359122; AAQ89956.1; -; mRNA.
DR EMBL; AY518533; AAR89910.1; -; Genomic_DNA.
DR EMBL; BC000980; AAH00980.1; -; mRNA.
DR CCDS; CCDS2874.1; -. [Q9NRM6-1]
DR RefSeq; NP_061195.2; NM_018725.3. [Q9NRM6-1]
DR AlphaFoldDB; Q9NRM6; -.
DR SMR; Q9NRM6; -.
DR BioGRID; 120708; 46.
DR IntAct; Q9NRM6; 24.
DR STRING; 9606.ENSP00000288167; -.
DR GlyGen; Q9NRM6; 6 sites.
DR iPTMnet; Q9NRM6; -.
DR PhosphoSitePlus; Q9NRM6; -.
DR BioMuta; IL17RB; -.
DR DMDM; 21263748; -.
DR MassIVE; Q9NRM6; -.
DR MaxQB; Q9NRM6; -.
DR PaxDb; Q9NRM6; -.
DR PeptideAtlas; Q9NRM6; -.
DR PRIDE; Q9NRM6; -.
DR ProteomicsDB; 82390; -. [Q9NRM6-1]
DR ABCD; Q9NRM6; 3 sequenced antibodies.
DR Antibodypedia; 1155; 502 antibodies from 34 providers.
DR DNASU; 55540; -.
DR Ensembl; ENST00000288167.8; ENSP00000288167.3; ENSG00000056736.10. [Q9NRM6-1]
DR GeneID; 55540; -.
DR KEGG; hsa:55540; -.
DR MANE-Select; ENST00000288167.8; ENSP00000288167.3; NM_018725.4; NP_061195.2.
DR UCSC; uc003dha.4; human. [Q9NRM6-1]
DR CTD; 55540; -.
DR DisGeNET; 55540; -.
DR GeneCards; IL17RB; -.
DR HGNC; HGNC:18015; IL17RB.
DR HPA; ENSG00000056736; Tissue enhanced (brain, kidney, liver).
DR MIM; 605458; gene.
DR neXtProt; NX_Q9NRM6; -.
DR OpenTargets; ENSG00000056736; -.
DR PharmGKB; PA29796; -.
DR VEuPathDB; HostDB:ENSG00000056736; -.
DR eggNOG; ENOG502RD98; Eukaryota.
DR GeneTree; ENSGT00940000161145; -.
DR HOGENOM; CLU_037593_0_0_1; -.
DR InParanoid; Q9NRM6; -.
DR OMA; HKYMVVY; -.
DR OrthoDB; 577180at2759; -.
DR PhylomeDB; Q9NRM6; -.
DR TreeFam; TF329644; -.
DR PathwayCommons; Q9NRM6; -.
DR Reactome; R-HSA-448424; Interleukin-17 signaling.
DR SignaLink; Q9NRM6; -.
DR SIGNOR; Q9NRM6; -.
DR BioGRID-ORCS; 55540; 4 hits in 1074 CRISPR screens.
DR ChiTaRS; IL17RB; human.
DR GeneWiki; IL17RB; -.
DR GenomeRNAi; 55540; -.
DR Pharos; Q9NRM6; Tbio.
DR PRO; PR:Q9NRM6; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9NRM6; protein.
DR Bgee; ENSG00000056736; Expressed in nephron tubule and 147 other tissues.
DR ExpressionAtlas; Q9NRM6; baseline and differential.
DR Genevisible; Q9NRM6; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0004896; F:cytokine receptor activity; NAS:UniProtKB.
DR GO; GO:0030368; F:interleukin-17 receptor activity; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; TAS:ProtInc.
DR GO; GO:0001558; P:regulation of cell growth; NAS:UniProtKB.
DR Gene3D; 2.60.40.2150; -; 1.
DR Gene3D; 2.60.40.2160; -; 1.
DR InterPro; IPR039465; IL-17_rcpt-like.
DR InterPro; IPR032356; IL17R_fnIII_D1.
DR InterPro; IPR038683; IL17RA/B_FnIII-like_1_sf.
DR InterPro; IPR043046; IL17RA/B_FnIII-like_2_sf.
DR InterPro; IPR013568; SEFIR_dom.
DR PANTHER; PTHR15583; PTHR15583; 1.
DR Pfam; PF16556; IL17R_fnIII_D1; 1.
DR Pfam; PF08357; SEFIR; 1.
DR PROSITE; PS51534; SEFIR; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Direct protein sequencing;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Secreted; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000269|PubMed:10749887,
FT ECO:0000269|PubMed:15340161"
FT CHAIN 18..502
FT /note="Interleukin-17 receptor B"
FT /id="PRO_0000011032"
FT TOPO_DOM 18..292
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..502
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 331..477
FT /note="SEFIR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00867"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 283
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 250..288
FT /note="LTPYFPTCGSDCIRHKGTVVLCPQTGVPFPLDNNKSKPG -> VKFSELLWG
FT GKGHRRLFHHSLLLRMSSLLSNALLPADTS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10815801"
FT /id="VSP_001740"
FT VAR_SEQ 289..502
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10815801"
FT /id="VSP_001741"
FT VARIANT 177
FT /note="G -> R (in dbSNP:rs2232337)"
FT /id="VAR_059304"
FT VARIANT 209
FT /note="A -> V (in dbSNP:rs2232340)"
FT /id="VAR_049178"
FT VARIANT 232
FT /note="R -> Q (in dbSNP:rs2232343)"
FT /id="VAR_049179"
FT VARIANT 278
FT /note="F -> L (in dbSNP:rs2232346)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_019209"
FT VARIANT 451
FT /note="I -> T (in dbSNP:rs2232350)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_019210"
FT VARIANT 458
FT /note="N -> S (in dbSNP:rs2232351)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_019211"
FT VARIANT 499
FT /note="C -> R (in dbSNP:rs28385751)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_019212"
FT CONFLICT 6
FT /note="L -> I (in Ref. 1; AAF86051/AAF86052)"
FT /evidence="ECO:0000305"
FT CONFLICT 422..426
FT /note="LFPLA -> SSPCL (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 427..502
FT /note="Missing (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 468
FT /note="L -> F (in Ref. 1; AAF86051)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 502 AA; 55885 MW; CDB87586FAAE49CC CRC64;
MSLVLLSLAA LCRSAVPREP TVQCGSETGP SPEWMLQHDL IPGDLRDLRV EPVTTSVATG
DYSILMNVSW VLRADASIRL LKATKICVTG KSNFQSYSCV RCNYTEAFQT QTRPSGGKWT
FSYIGFPVEL NTVYFIGAHN IPNANMNEDG PSMSVNFTSP GCLDHIMKYK KKCVKAGSLW
DPNITACKKN EETVEVNFTT TPLGNRYMAL IQHSTIIGFS QVFEPHQKKQ TRASVVIPVT
GDSEGATVQL TPYFPTCGSD CIRHKGTVVL CPQTGVPFPL DNNKSKPGGW LPLLLLSLLV
ATWVLVAGIY LMWRHERIKK TSFSTTTLLP PIKVLVVYPS EICFHHTICY FTEFLQNHCR
SEVILEKWQK KKIAEMGPVQ WLATQKKAAD KVVFLLSNDV NSVCDGTCGK SEGSPSENSQ
DLFPLAFNLF CSDLRSQIHL HKYVVVYFRE IDTKDDYNAL SVCPKYHLMK DATAFCAELL
HVKQQVSAGK RSQACHDGCC SL
