I17RB_MOUSE
ID I17RB_MOUSE Reviewed; 499 AA.
AC Q9JIP3; Q9JIP2;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Interleukin-17 receptor B;
DE Short=IL-17 receptor B;
DE Short=IL-17RB;
DE AltName: Full=IL-17 receptor homolog 1;
DE Short=IL-17ER;
DE Short=IL-17Rh1;
DE Short=IL17Rh1;
DE AltName: Full=Interleukin-17B receptor;
DE Short=IL-17B receptor;
DE Flags: Precursor;
GN Name=Il17rb; Synonyms=Evi27, Il17br;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=10815801; DOI=10.1038/sj.onc.1203577;
RA Tian E., Sawyer J.R., Largaespada D.A., Jenkins N.A., Copeland N.G.,
RA Shaughnessy J.D. Jr.;
RT "Evi27 encodes a novel membrane protein with homology to the IL17
RT receptor.";
RL Oncogene 19:2098-2109(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for the pro-inflammatory cytokines IL17B and IL17E.
CC May play a role in controlling the growth and/or differentiation of
CC hematopoietic cells.
CC -!- SUBUNIT: Interacts with DAZAP2. Interacts with TRAF3IP2.
CC {ECO:0000250|UniProtKB:Q9NRM6}.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I
CC membrane protein.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9JIP3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9JIP3-2; Sequence=VSP_001742, VSP_001743;
CC -!- TISSUE SPECIFICITY: Liver and testis. Expressed at lower level in
CC kidney and lung. Expressed in selected T-cell, B-cell and myeloid cell
CC lines.
CC -!- MISCELLANEOUS: Evi27 is a common site of retroviral integration in Bxh2
CC murine myeloid leukemias, localized near the Il17rb gene. Proviral
CC integrations result in increased expression of Il17rb on the cell
CC surface.
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DR EMBL; AF208108; AAF86049.1; -; mRNA.
DR EMBL; AF208109; AAF86050.1; -; mRNA.
DR EMBL; BC026546; AAH26546.1; -; mRNA.
DR CCDS; CCDS36845.1; -. [Q9JIP3-1]
DR RefSeq; NP_062529.2; NM_019583.3. [Q9JIP3-1]
DR PDB; 3VBC; X-ray; 1.80 A; A=325-486.
DR PDBsum; 3VBC; -.
DR AlphaFoldDB; Q9JIP3; -.
DR SMR; Q9JIP3; -.
DR BioGRID; 206146; 2.
DR IntAct; Q9JIP3; 1.
DR STRING; 10090.ENSMUSP00000016110; -.
DR GlyGen; Q9JIP3; 4 sites.
DR iPTMnet; Q9JIP3; -.
DR PhosphoSitePlus; Q9JIP3; -.
DR PaxDb; Q9JIP3; -.
DR PRIDE; Q9JIP3; -.
DR ProteomicsDB; 273070; -. [Q9JIP3-1]
DR ProteomicsDB; 273071; -. [Q9JIP3-2]
DR ABCD; Q9JIP3; 6 sequenced antibodies.
DR Antibodypedia; 1155; 502 antibodies from 34 providers.
DR DNASU; 50905; -.
DR Ensembl; ENSMUST00000016110; ENSMUSP00000016110; ENSMUSG00000015966. [Q9JIP3-1]
DR GeneID; 50905; -.
DR KEGG; mmu:50905; -.
DR UCSC; uc007sun.1; mouse. [Q9JIP3-1]
DR CTD; 55540; -.
DR MGI; MGI:1355292; Il17rb.
DR VEuPathDB; HostDB:ENSMUSG00000015966; -.
DR eggNOG; ENOG502RD98; Eukaryota.
DR GeneTree; ENSGT00940000161145; -.
DR HOGENOM; CLU_037593_0_0_1; -.
DR InParanoid; Q9JIP3; -.
DR OMA; HKYMVVY; -.
DR BioGRID-ORCS; 50905; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q9JIP3; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q9JIP3; protein.
DR Bgee; ENSMUSG00000015966; Expressed in secondary oocyte and 95 other tissues.
DR ExpressionAtlas; Q9JIP3; baseline and differential.
DR Genevisible; Q9JIP3; MM.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0004896; F:cytokine receptor activity; ISS:MGI.
DR GO; GO:0030368; F:interleukin-17 receptor activity; IBA:GO_Central.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IMP:MGI.
DR GO; GO:0032736; P:positive regulation of interleukin-13 production; IMP:MGI.
DR GO; GO:0032754; P:positive regulation of interleukin-5 production; IMP:MGI.
DR Gene3D; 2.60.40.2150; -; 1.
DR Gene3D; 2.60.40.2160; -; 1.
DR InterPro; IPR039465; IL-17_rcpt-like.
DR InterPro; IPR032356; IL17R_fnIII_D1.
DR InterPro; IPR038683; IL17RA/B_FnIII-like_1_sf.
DR InterPro; IPR043046; IL17RA/B_FnIII-like_2_sf.
DR InterPro; IPR013568; SEFIR_dom.
DR PANTHER; PTHR15583; PTHR15583; 1.
DR Pfam; PF16556; IL17R_fnIII_D1; 1.
DR Pfam; PF08357; SEFIR; 1.
DR PROSITE; PS51534; SEFIR; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cell membrane; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Secreted; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000250"
FT CHAIN 18..499
FT /note="Interleukin-17 receptor B"
FT /id="PRO_0000011033"
FT TOPO_DOM 18..286
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..499
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 328..474
FT /note="SEFIR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00867"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 163..218
FT /note="LNHVMKYKKQCTEAGSLWDPDITACKKNEKMVEVNFTTNPLGNRYTILIQRD
FT TTLG -> TRENTEVTSGVFPAAKHQALRISAPFPLQFPPGPEDSVILPPQPLASLFHD
FT FVKLT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10815801"
FT /id="VSP_001742"
FT VAR_SEQ 219..499
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10815801"
FT /id="VSP_001743"
FT STRAND 329..334
FT /evidence="ECO:0007829|PDB:3VBC"
FT HELIX 339..341
FT /evidence="ECO:0007829|PDB:3VBC"
FT HELIX 342..354
FT /evidence="ECO:0007829|PDB:3VBC"
FT STRAND 358..362
FT /evidence="ECO:0007829|PDB:3VBC"
FT HELIX 363..365
FT /evidence="ECO:0007829|PDB:3VBC"
FT HELIX 367..373
FT /evidence="ECO:0007829|PDB:3VBC"
FT HELIX 375..385
FT /evidence="ECO:0007829|PDB:3VBC"
FT STRAND 387..393
FT /evidence="ECO:0007829|PDB:3VBC"
FT HELIX 419..427
FT /evidence="ECO:0007829|PDB:3VBC"
FT HELIX 428..430
FT /evidence="ECO:0007829|PDB:3VBC"
FT STRAND 434..436
FT /evidence="ECO:0007829|PDB:3VBC"
FT STRAND 440..444
FT /evidence="ECO:0007829|PDB:3VBC"
FT HELIX 455..459
FT /evidence="ECO:0007829|PDB:3VBC"
FT STRAND 462..464
FT /evidence="ECO:0007829|PDB:3VBC"
FT TURN 465..468
FT /evidence="ECO:0007829|PDB:3VBC"
FT HELIX 469..478
FT /evidence="ECO:0007829|PDB:3VBC"
SQ SEQUENCE 499 AA; 55617 MW; C66440430E3C31F3 CRC64;
MLLVLLILAA SCRSALPREP TIQCGSETGP SPEWMVQHTL TPGDLRDLQV ELVKTSVAAE
EFSILMNISW ILRADASIRL LKATKICVSG KNNMNSYSCV RCNYTEAFQS QTRPSGGKWT
FSYVGFPVEL STLYLISAHN IPNANMNEDS PSLSVNFTSP GCLNHVMKYK KQCTEAGSLW
DPDITACKKN EKMVEVNFTT NPLGNRYTIL IQRDTTLGFS RVLENKLMRT SVAIPVTEES
EGAVVQLTPY LHTCGNDCIR REGTVVLCSE TSAPIPPDDN RRMLGGWLPL FLVLLVAVWV
LAAGIYLTWR QGRSTKTSFP ISTMLLPLIK VLVVYPSEIC FHHTVCRFTD FLQNYCRSEV
ILEKWQKKKI AEMGPVQWLT TQKQAADKVV FLLPSDVPTL CDSACGHNEG SARENSQDLF
PLAFNLFCSD FSSQTHLHKY LVVYLGGADL KGDYNALSVC PQYHLMKDAT AFHTELLKAT
QSMSVKKRSQ ACHDSCSPL