I17RE_HUMAN
ID I17RE_HUMAN Reviewed; 667 AA.
AC Q8NFR9; B2RB34; B2RNR1; B9EH65; Q6P532; Q8N8H7; Q8N8H8; Q8TEC2;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Interleukin-17 receptor E;
DE Short=IL-17 receptor E;
DE Short=IL-17RE;
DE Flags: Precursor;
GN Name=IL17RE; ORFNames=UNQ3056/PRO9877;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Gilbert J.M., Gorman D.M.;
RT "Identification of novel IL-17 related receptors.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
RC TISSUE=Colon mucosa, Prostate, and Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
RC TISSUE=Lung, Skin, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=16310341; DOI=10.1016/j.cellsig.2005.10.010;
RA Li T.-S., Li X.-N., Chang Z.-J., Fu X.-Y., Liu L.;
RT "Identification and functional characterization of a novel interleukin 17
RT receptor: a possible mitogenic activation through ras/mitogen-activated
RT protein kinase signaling pathway.";
RL Cell. Signal. 18:1287-1298(2006).
RN [7]
RP FUNCTION, AND IDENTIFICATION AS IL17C RECEPTOR.
RX PubMed=21993849; DOI=10.1038/ni.2155;
RA Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y.;
RT "IL-17RE is the functional receptor for IL-17C and mediates mucosal
RT immunity to infection with intestinal pathogens.";
RL Nat. Immunol. 12:1151-1158(2011).
RN [8]
RP FUNCTION, IDENTIFICATION AS IL17C RECEPTOR, INTERACTION WITH IL17RA, AND
RP TISSUE SPECIFICITY.
RX PubMed=21993848; DOI=10.1038/ni.2156;
RA Ramirez-Carrozzi V., Sambandam A., Luis E., Lin Z., Jeet S., Lesch J.,
RA Hackney J., Kim J., Zhou M., Lai J., Modrusan Z., Sai T., Lee W., Xu M.,
RA Caplazi P., Diehl L., de Voss J., Balazs M., Gonzalez L. Jr., Singh H.,
RA Ouyang W., Pappu R.;
RT "IL-17C regulates the innate immune function of epithelial cells in an
RT autocrine manner.";
RL Nat. Immunol. 12:1159-1166(2011).
CC -!- FUNCTION: Specific functional receptor for IL17C. May be signaling
CC through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1
CC for signaling. May be a crucial regulator in innate immunity to
CC bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic
CC inactive or dominant active forms. Isoform 3 and isoform 5 may act as
CC soluble decoy receptors. {ECO:0000269|PubMed:21993848,
CC ECO:0000269|PubMed:21993849}.
CC -!- SUBUNIT: Forms heterodimers with IL17RA; the heterodimer binds IL17C.
CC -!- INTERACTION:
CC Q8NFR9; Q96F46: IL17RA; NbExp=2; IntAct=EBI-5591275, EBI-5591258;
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250}; Single-
CC pass type I membrane protein {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q8NFR9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NFR9-2; Sequence=VSP_029190;
CC Name=3;
CC IsoId=Q8NFR9-3; Sequence=VSP_029193, VSP_029196;
CC Name=4;
CC IsoId=Q8NFR9-4; Sequence=VSP_029190, VSP_029194, VSP_029195;
CC Name=5;
CC IsoId=Q8NFR9-5; Sequence=VSP_029191, VSP_029192;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in mucosal tissues with
CC high levels in keratinocytes and colon epithelial cells. Very low
CC expression in dermal fibroblasts. Expressed in various tumor cell
CC lines. {ECO:0000269|PubMed:16310341, ECO:0000269|PubMed:21993848}.
CC -!- SEQUENCE CAUTION: [Isoform 3]:
CC Sequence=BAB85028.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF458069; AAM77573.1; -; mRNA.
DR EMBL; AY358451; AAQ88816.1; -; mRNA.
DR EMBL; AK074238; BAB85028.1; ALT_FRAME; mRNA.
DR EMBL; AK096793; BAC04863.1; -; mRNA.
DR EMBL; AK096801; BAC04864.1; -; mRNA.
DR EMBL; AK314476; BAG37081.1; -; mRNA.
DR EMBL; CH471055; EAW64019.1; -; Genomic_DNA.
DR EMBL; CH471055; EAW64020.1; -; Genomic_DNA.
DR EMBL; CH471055; EAW64016.1; -; Genomic_DNA.
DR EMBL; BC063110; AAH63110.1; -; mRNA.
DR EMBL; BC137077; AAI37078.1; -; mRNA.
DR EMBL; BC137078; AAI37079.1; -; mRNA.
DR CCDS; CCDS2589.1; -. [Q8NFR9-1]
DR CCDS; CCDS54552.1; -. [Q8NFR9-3]
DR RefSeq; NP_001180309.1; NM_001193380.1. [Q8NFR9-3]
DR RefSeq; NP_705613.1; NM_153480.1. [Q8NFR9-1]
DR RefSeq; NP_705614.1; NM_153481.1. [Q8NFR9-2]
DR RefSeq; NP_705616.2; NM_153483.2.
DR RefSeq; XP_006713039.1; XM_006712976.1. [Q8NFR9-2]
DR AlphaFoldDB; Q8NFR9; -.
DR SMR; Q8NFR9; -.
DR BioGRID; 126304; 26.
DR IntAct; Q8NFR9; 10.
DR STRING; 9606.ENSP00000373325; -.
DR GlyGen; Q8NFR9; 3 sites.
DR iPTMnet; Q8NFR9; -.
DR PhosphoSitePlus; Q8NFR9; -.
DR BioMuta; IL17RE; -.
DR DMDM; 74730297; -.
DR MassIVE; Q8NFR9; -.
DR PaxDb; Q8NFR9; -.
DR PeptideAtlas; Q8NFR9; -.
DR PRIDE; Q8NFR9; -.
DR ProteomicsDB; 73342; -. [Q8NFR9-1]
DR ProteomicsDB; 73343; -. [Q8NFR9-2]
DR Antibodypedia; 2563; 324 antibodies from 31 providers.
DR DNASU; 132014; -.
DR Ensembl; ENST00000383814.8; ENSP00000373325.3; ENSG00000163701.19. [Q8NFR9-1]
DR Ensembl; ENST00000454190.6; ENSP00000388086.2; ENSG00000163701.19. [Q8NFR9-3]
DR GeneID; 132014; -.
DR KEGG; hsa:132014; -.
DR MANE-Select; ENST00000383814.8; ENSP00000373325.3; NM_153480.2; NP_705613.1.
DR UCSC; uc003btw.4; human. [Q8NFR9-1]
DR CTD; 132014; -.
DR DisGeNET; 132014; -.
DR GeneCards; IL17RE; -.
DR HGNC; HGNC:18439; IL17RE.
DR HPA; ENSG00000163701; Tissue enhanced (intestine, skin).
DR MIM; 614995; gene.
DR neXtProt; NX_Q8NFR9; -.
DR OpenTargets; ENSG00000163701; -.
DR PharmGKB; PA134896136; -.
DR VEuPathDB; HostDB:ENSG00000163701; -.
DR eggNOG; ENOG502QU0I; Eukaryota.
DR GeneTree; ENSGT00940000161421; -.
DR HOGENOM; CLU_026094_0_0_1; -.
DR InParanoid; Q8NFR9; -.
DR OMA; RIHATFS; -.
DR OrthoDB; 238258at2759; -.
DR PhylomeDB; Q8NFR9; -.
DR TreeFam; TF335690; -.
DR PathwayCommons; Q8NFR9; -.
DR Reactome; R-HSA-448424; Interleukin-17 signaling.
DR SignaLink; Q8NFR9; -.
DR BioGRID-ORCS; 132014; 12 hits in 1067 CRISPR screens.
DR GenomeRNAi; 132014; -.
DR Pharos; Q8NFR9; Tbio.
DR PRO; PR:Q8NFR9; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8NFR9; protein.
DR Bgee; ENSG00000163701; Expressed in skin of leg and 92 other tissues.
DR ExpressionAtlas; Q8NFR9; baseline and differential.
DR Genevisible; Q8NFR9; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0030368; F:interleukin-17 receptor activity; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR InterPro; IPR039465; IL-17_rcpt-like.
DR InterPro; IPR027841; IL-17_rcpt_C/E_N.
DR InterPro; IPR013568; SEFIR_dom.
DR PANTHER; PTHR15583; PTHR15583; 1.
DR Pfam; PF15037; IL17_R_N; 2.
DR Pfam; PF08357; SEFIR; 2.
DR PROSITE; PS51534; SEFIR; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Cytoplasm; Glycoprotein;
KW Inflammatory response; Membrane; Receptor; Reference proteome; Secreted;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..667
FT /note="Interleukin-17 receptor E"
FT /id="PRO_0000309467"
FT TOPO_DOM 24..454
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 476..667
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 487..624
FT /note="SEFIR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00867"
FT REGION 126..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 318
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 347
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 364
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..116
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029190"
FT VAR_SEQ 268..271
FT /note="YGSD -> CECC (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029191"
FT VAR_SEQ 272..667
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029192"
FT VAR_SEQ 433..533
FT /note="VWRSDVQFAWKHLLCPDVSYRHLGLLILALLALLTLLGVVLALTCRRPQSGP
FT GPARPVLLLHAADSEAQRRLVGALAELLRAALGGGRDVIVDLWEGRHVA -> LHASLS
FT SPGGEDAWLIGVGGSVPSGVAVRCPVCLEAPLVSGCLLQTPGALDPGTAGPPHPTGCCS
FT GPHLPAPTVRPGPSAASAPPARGGLGGAAAPGGSAG (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029193"
FT VAR_SEQ 433..506
FT /note="VWRSDVQFAWKHLLCPDVSYRHLGLLILALLALLTLLGVVLALTCRRPQSGP
FT GPARPVLLLHAADSEAQRRLVG -> ASSWSRHKPTWEEFPSQWGLPSPPAPCFTQLPG
FT RRRCLAHRGGGLCALRCGGQMSSLPGSTSCVRMSLTDTWGS (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029194"
FT VAR_SEQ 507..667
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029195"
FT VAR_SEQ 534..667
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029196"
FT VARIANT 219
FT /note="Y -> C (in dbSNP:rs7356031)"
FT /id="VAR_036956"
FT VARIANT 402
FT /note="P -> S (in dbSNP:rs9870003)"
FT /id="VAR_036957"
FT VARIANT 417
FT /note="S -> T (in dbSNP:rs7647642)"
FT /id="VAR_036958"
FT CONFLICT 270
FT /note="S -> P (in Ref. 3; BAC04864)"
FT /evidence="ECO:0000305"
FT CONFLICT 445
FT /note="L -> F (in Ref. 3; BAC04864)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 667 AA; 74810 MW; 1493744E7354067D CRC64;
MGSSRLAALL LPLLLIVIDL SDSAGIGFRH LPHWNTRCPL ASHTDDSFTG SSAYIPCRTW
WALFSTKPWC VRVWHCSRCL CQHLLSGGSG LQRGLFHLLV QKSKKSSTFK FYRRHKMPAP
AQRKLLPRRH LSEKSHHISI PSPDISHKGL RSKRTQPSDP ETWESLPRLD SQRHGGPEFS
FDLLPEARAI RVTISSGPEV SVRLCHQWAL ECEELSSPYD VQKIVSGGHT VELPYEFLLP
CLCIEASYLQ EDTVRRKKCP FQSWPEAYGS DFWKSVHFTD YSQHTQMVMA LTLRCPLKLE
AALCQRHDWH TLCKDLPNAT ARESDGWYVL EKVDLHPQLC FKFSFGNSSH VECPHQTGSL
TSWNVSMDTQ AQQLILHFSS RMHATFSAAW SLPGLGQDTL VPPVYTVSQA RGSSPVSLDL
IIPFLRPGCC VLVWRSDVQF AWKHLLCPDV SYRHLGLLIL ALLALLTLLG VVLALTCRRP
QSGPGPARPV LLLHAADSEA QRRLVGALAE LLRAALGGGR DVIVDLWEGR HVARVGPLPW
LWAARTRVAR EQGTVLLLWS GADLRPVSGP DPRAAPLLAL LHAAPRPLLL LAYFSRLCAK
GDIPPPLRAL PRYRLLRDLP RLLRALDARP FAEATSWGRL GARQRRQSRL ELCSRLEREA
ARLADLG
